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HIV, Chlamydia trachomatis and Helicobacter pylori vaccine antigen and proteinaceous adjuvant production in arabidopsis and carrot
Örebro University, School of Science and Technology. (Biokemi)ORCID iD: 0000-0003-3315-8835
Örebro University, School of Science and Technology. (Biokemi)
Örebro University, School of Science and Technology. (Biokemi)
Smittskyddsinstitutet, The Public Health Agency, Solna, Sweden.
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2010 (English)In: Molecular farming: plant as a production platform for high value proteins / [ed] Nunzia Scotti, Bryssel: COST , 2010, p. 17-17Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

In our project, we use plants for synthesis of vaccine antigens and adjuvant proteins. Among targeted diseases are HIV, Chlamydia trachomatis (CT) and Helicobacter pylori (HP) infections. Novel genetic constructs have been designed for production of optimized antigen proteins and several transformation techniques and intracellular protein production sites are being examined for yield optimization. Both Arabidopsis thaliana (HIV, CT, HP) and carrot (HIV, CT) have been successfully used as production hosts and plant-produced antigens against HIV (primarily the p24 protein), CT (own designed chimera of the MOMP protein) and HP (different versions of the TonB protein). For HIV and CT these antigens have been used in immunization trials in laboratory mice, giving rise to systemic immune responses. For this purpose both consumption of plant tissue and distribution of purified antigens have been used. For CT, the administration of the recombinant protein has also been shown to protect against the disease in mice. Moreover, to further increase the effect of vaccine antigens, we also use plants to produce protein-based adjuvants for inclusion in vaccine formulations. These adjuvants are based either on the bacterial flagellin protein or are cholera toxin-derived chimeric proteins.

Place, publisher, year, edition, pages
Bryssel: COST , 2010. p. 17-17
National Category
Plant Biotechnology
Research subject
Biochemistry
Identifiers
URN: urn:nbn:se:oru:diva-24333OAI: oai:DiVA.org:oru-24333DiVA, id: diva2:543782
Conference
COST Action FA0804, Vico Equense (NA), Italy, October 6-8, 2010
Available from: 2012-08-09 Created: 2012-08-09 Last updated: 2018-04-24Bibliographically approved

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http://molfarm.ueb.cas.cz/Book%20of%20Abstracts%20COST%20FA0804%20VicoOct2010.pdf

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Strid, ÅkeLindh, IngridKalbina, IrinaAndersson, Sören

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