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Plant-based production of vaccine antigens and adjuvants
Örebro University, School of Science and Technology. (Biokemi)ORCID iD: 0000-0003-3315-8835
Örebro University, School of Science and Technology. (Biokemi)
Örebro University, School of Science and Technology. (Biokemi)
Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0002-4522-3078
2010 (English)Conference paper, Oral presentation only (Refereed)
Abstract [en]

Vaccination is the most successful form of prevention of infectious diseases but only a few dozen of several hundred infectious diseases can be prevented in this way due to the extreme cost of vaccine development and due to costly production. Obviously, there is a growing need for large scale and low cost production of valuable proteins, such as vaccine antigens, and alternative methods to mammalian and microbial production systems are also desirable. Plants/plant cells may offer such an option. In our project, we use plants for synthesis of vaccine antigens and adjuvant proteins. Among targeted diseases are HIV, Chlamydia trachomatis (CT) and Helicobacter pylori infections. Novel genetic constructs have been designed for production of optimized antigen proteins and several transformation techniques and intracellular protein production sites are being examined for yield optimization. Both Arabidopsis and carrot have been succesfully used as production hosts and plant-produced antigens against HIV and CT have been used in immunization trials in laboratory mice, giving rise to systemic immune responses. For CT, our designed chimeric protein has also been shown to protect against the disease. Moreover, to further increase the effect of vaccine antigens, we also use plants to produce protein-based adjuvants for inclusion in vaccine formulations. This project is part of the transnational COST network FA0804: ‘Molecular farming - plants as production platform for high-value proteins’. A few slides will be devoted to the brief presentation of the collaboration within this network, which is comprised of research groups in 23 EU countries and a few associated groups outside EU.

Place, publisher, year, edition, pages
2010.
National Category
Plant Biotechnology
Research subject
Biochemistry
Identifiers
URN: urn:nbn:se:oru:diva-24349OAI: oai:DiVA.org:oru-24349DiVA, id: diva2:543866
Conference
Queenstown Molecular Biology Congress, Plant Satellite Meeting, Queenstown, New Zealand, August 29-31, 2010
Available from: 2012-08-10 Created: 2012-08-10 Last updated: 2018-04-24Bibliographically approved

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Strid, ÅkeLindh, IngridKalbina, IrinaAndersson, Sören

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
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  • asciidoc
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