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Milk fat globule membrane (INPULSE) enriched formula milk decreases febrile episodes and may improve behavioral regulation in young children
Pediatric GI & Nutrition, Queen Paola Children’s Hospital–ZNA, Antwerp, Belgium.
Pediatric GI & Nutrition, Queen Paola Children’s Hospital–ZNA, Antwerp, Belgium.
Laboratory of Food Technology and Engineering, Ghent University, Gent, Belgium.
Laboratory of Food Technology and Engineering, Ghent University, Gent, Belgium.
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2012 (English)In: Nutrition (Burbank, Los Angeles County, Calif.), ISSN 0899-9007, E-ISSN 1873-1244, Vol. 28, no 7-8, p. 749-752Article in journal (Refereed) Published
Abstract [en]

Objective: Polar lipids constitute an important part of cellular membranes. The mucosal surface of the gastrointestinal tract is a critical barrier between noxious and immunogenic substances in the lumen and the mucosal immune system.

Methods: We conducted a prospective, double-blinded, randomized, controlled trial in healthy children to evaluate the acceptability, safety, effect on intestinal comfort (constipation), common infectious symptoms (fever, diarrhea, cough), and behavioral regulation of a 4-mo daily intake of 200-mL formula with or without enrichment of the milk fat globule membrane (INPULSE). Data were collected from parental diaries. The primary endpoints for analysis were the number of days with fever, diarrhea, coughing, or constipation. The secondary endpoints were the number of doctor visits, medication intake, number of missed schooldays, acceptability of the test drinks, and safety. The Achenbach System of Empirically Based Assessment, a validated questionnaire to assess behavior, was submitted to parents at the end of the intervention period.

Results: Initially 253 children were included, but 71 dropped out (these were subjects with <80% intake or for <90 d). No adverse effects led to the discontinuation. Per-protocol analysis was performed in 97 girls and 85 boys. The group (n = 182) was normally distributed, with a mean age of 4.4 +/- 0.9 y. The amount of product taken each day and the acceptability were similar in the intervention and control groups. The number of days with fever (>38.5 degrees C) and the number of short (<3 d) febrile periods were significantly (P < 0.03) decreased in the intervention group (1.7 +/- 2.5 vs 2.6 +/- 3.1 d) This significant difference in febrile episodes appeared after 6 wk cif consecutive intake. Other outcome parameters (diarrhea, constipation, cough, doctor visit, and days of school absence) were similar in the two groups. An analysis of the 169 Achenbach System of Empirically Based Assessment questionnaires (two-tailed t test) showed significant differences in the internal (P < 0.003), external (P < 0.004), and total (P < 0.002) problem scores in favor of the intervention group. Between-subjects effects were highly correlated (internal, P < 0.003; external, P < 0.005; total, P < 0.002, one-way analysis of variance).

Conclusion: Regular consumption of formula enriched with a concentrated milk fat membrane (INPULSE) product by preschool children was safe, well tolerated, and, based on per-protocol analysis, is associated with a significant decrease in the number of short febrile episodes and leads to improved behavioral regulation.

Place, publisher, year, edition, pages
New York, USA: Elsevier, 2012. Vol. 28, no 7-8, p. 749-752
Keywords [en]
Behavior, Children, Infections, Milk fat globule membrane, Nutraceutical, Polar lipids
National Category
Medical and Health Sciences Pediatrics
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-24626DOI: 10.1016/j.nut.2011.10.011ISI: 000305769500009PubMedID: 22305534Scopus ID: 2-s2.0-84862156477OAI: oai:DiVA.org:oru-24626DiVA, id: diva2:545810
Note

Funding Agencies:

Bullinger Butterei, Bullingen, Belgium

Lactel, Laval, France 

Available from: 2012-08-21 Created: 2012-08-21 Last updated: 2017-12-07Bibliographically approved

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Brummer, Robert

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School of Health and Medical Sciences, Örebro University, Sweden
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