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Aberrant Amino Acid Transport in Patients with Schizophrenia, Bipolar-I Disorders and Autism
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. (Experimental Neuropsychiatry)ORCID iD: 0000-0001-8102-1804
2011 (English)In: Psychiatry and the neurosciences: international perspectives, Bologna, Italy: Medimond, 2011, p. 155-161Conference paper, Published paper (Other academic)
Abstract [en]

Tyrosine and tryptophan are precursors to dopamine and serotonin and are involved in partial regulation of dopamine and serotonin synthesis. Changes in tyrosine and or tryptophan availability may influence dopamine-serotonin function that may cause widespread changes both in neurotransmission and psychopathology in patients with schizophrenia, bipolar-I and related CNS disorders. Competitive transport with other amino acids or aberrant transport of these precursors, across the cell membranes/blood brain barrier (BBB), can cause a limited availability of tyrosine and/or tryptophan to the brain. Transport of neutral amino acids including tyrosine, tryptophan and alanine, mainly occurs through L and A system and its isoforms. Evidence from different investigations of an aberrant amino acid transport in fibroblast cell obtain from patients with schizophrenia, bipolar-I disorders and autism, as well as the functionality and the relationship between tyrosine, tryptophan and alanine transport are touched on in this article

Place, publisher, year, edition, pages
Bologna, Italy: Medimond, 2011. p. 155-161
Series
Neurology, Psychiatry and the Neurosciences ; 50
Keywords [en]
Amino acid, transport, fibroblaster, schizophrenia, autism
National Category
Medical and Health Sciences
Research subject
Psychiatry; Biomedicine; Medicine
Identifiers
URN: urn:nbn:se:oru:diva-25374ISI: 000309762400020ISBN: 978-88-7587-618-0 (print)OAI: oai:DiVA.org:oru-25374DiVA, id: diva2:547305
Conference
the 4th International Congress on Psychiatry and the Neurosciences
Projects
Aminosyratransport i fibroblaster från patienter med schizofreni och bipolär sjukdom
Funder
Swedish Research Council, K2007-62X-08318Available from: 2012-08-30 Created: 2012-08-27 Last updated: 2018-05-04Bibliographically approved

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Venizelos, Nikolaos

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CiteExportLink to record
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Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
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Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf