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Infectious disease and risk of later celiac disease in childhood
Department of Medicine, Clinical Epidemiology Unit, Karolinska Institute, Stockholm, Sweden.
Clinical Research Centre, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0001-8126-9738
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Medicine, Clinical Epidemiology Unit, Karolinska Institute, Stockholm, Sweden; Clinical Research Centre, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0001-6328-5494
Division of Pediatrics, Linköping University, Linköping, Sweden; Diabetes Research Centre, Linköping University, Linköping, Sweden.
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2010 (English)In: Pediatrics, ISSN 0031-4005, E-ISSN 1098-4275, Vol. 125, no 3, p. e530-e536Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: The goal was to examine whether parent-reported infection at the time of gluten introduction increases the risk of future celiac disease (CD).

METHODS: Through the population-based All Infants in Southeast Sweden study, parents recorded data on feeding and infectious disease prospectively. Complete data on gluten introduction and breastfeeding duration were available for 9408 children. Those children had 42 826 parent-reported episodes of infectious disease in the first year of life (including 4003 episodes of gastroenteritis). We identified 44 children with biopsy-verified CD diagnosed after 1 year of age, and we used Cox regression to estimate the risk of future CD for children with infection at gluten introduction.

RESULTS: Eighteen children with CD (40.9%) had an infection at the time of gluten introduction, compared with 2510 reference individuals (26.8%; P = .035). Few children had gastroenteritis at the time of gluten introduction (1 child with CD [2.3%] vs 166 reference individuals [1.8%]; P = .546). With adjustment for age at gluten introduction and breastfeeding duration, we found no association between a future diagnosis of CD and either any infection (adjusted hazard ratio: 1.8 [95% confidence interval: 0.9-3.6]) or gastroenteritis (adjusted hazard ratio: 2.6 [95% confidence interval: 0.2-30.8]) at the time of gluten introduction. We found no associations between breastfeeding duration, age at gluten introduction, and future CD.

CONCLUSION: These results indicate that parent-reported infection at the time of gluten introduction is not a major risk factor for CD.

Place, publisher, year, edition, pages
2010. Vol. 125, no 3, p. e530-e536
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Medical and Health Sciences
Research subject
Medicine
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URN: urn:nbn:se:oru:diva-25566DOI: 10.1542/peds.2009-1200ISI: 000275945700040PubMedID: 20176673OAI: oai:DiVA.org:oru-25566DiVA, id: diva2:548087
Available from: 2012-08-29 Created: 2012-08-29 Last updated: 2019-02-28Bibliographically approved

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Röckert Tjernberg, AnnaMontgomery, Scott M.Ludvigsson, Jonas F

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