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Neuroradiology can predict the development of hand function in children with unilateral cerebral palsy
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.ORCID iD: 0000-0001-5418-3154
Karolinska University Hospital, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
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2013 (English)In: Neurorehabilitation and Neural Repair, ISSN 1545-9683, E-ISSN 1552-6844, Vol. 27, no 1, p. 72-78Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Much variation is found in the development of hand function in children with unilateral cerebral palsy (CP).

OBJECTIVE: To explore how anatomic brain abnormalities can be used to predict the development of hand function.

METHODS: A total of 32 children with unilateral CP (16 boys and 16 girls) were evaluated at least once a year by the Assisting Hand Assessment (AHA). The data collection covered an age range from 18 months to 8 years (mean time in study, 4 years and 6 months). Computerized tomography or magnetic resonance imaging of the brain were assessed for patterns of brain damage, including the location of gray and extent of white-matter damage. The children were divided into groups according to lesion characteristics, and a series of univariate models were analyzed with a nonlinear mixed-effects model. The rate and maximum limit of development were calculated.

RESULTS: The highest predictive power of better development of hand function was the absence of a concurrent lesion to the basal ganglia and thalamus, independent of the basic type of brain lesion. This model predicted both the rate of increasing ability and hand function at age 8 years. Hand function was also predicted by the basic pattern of damage and by the extent of white-matter damage. The presence of unilateral or bilateral damage had no predictive value.

CONCLUSIONS: Neuroradiological findings can be used to make a crude prediction of the future development of the use of the affected hand in young children with unilateral CP.

Place, publisher, year, edition, pages
Sage Publications, 2013. Vol. 27, no 1, p. 72-78
Keywords [en]
cerebral palsy, child development, brain injuries, magnetic resonance imaging, motor skills, rehabilitation, predictive models
National Category
Occupational Therapy
Research subject
Occupational therapy
Identifiers
URN: urn:nbn:se:oru:diva-25847DOI: 10.1177/1545968312446950ISI: 000311853400008PubMedID: 22677505Scopus ID: 2-s2.0-84870606817OAI: oai:DiVA.org:oru-25847DiVA, id: diva2:553239
Funder
Swedish Research Council, K2009-63X14534-07-3
Note

Funding Agency:

Promobilia Foundation 

Sunnerdahl Foundation 

Centre for Health Care Sciences at Karolinska Institutet 

Strategic Research Programme in Care Sciences and Vinnova 

Available from: 2012-09-18 Created: 2012-09-14 Last updated: 2019-03-04Bibliographically approved

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Holmefur, MarieEliasson, Ann-Christin

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