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Total adiponectin does not predict cardiovascular events in middle-aged men in a prospective, long-term follow-up study
Örebro University, School of Health and Medical Sciences.
Inst Clin, Med Res Labs, Aarhus Univ Hosp, Aarhus, Denmark.
Inst Clin, Med Res Labs, Aarhus Univ Hosp, Aarhus, Denmark.
Varmland Cty Res Council, Karlstad, Sweden .
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2010 (English)In: Diabetes & Metabolism, ISSN 1262-3636, E-ISSN 1878-1780, Vol. 36, no 2, p. 137-143Article in journal (Refereed) Published
Abstract [en]

Aim. Plasma total adiponectin is a marker of insulin resistance, but its role in predicting cardiovascular events is unclear. We aimed to investigate the role of adiponectin as a predictor of cardiovascular risk in middle-aged men, and to describe the association between adiponectin and glucose metabolism.

Methods. In this population-based prospective study of middle-aged men (n=3885), total adiponectin was analyzed. All individuals had undergone an oral glucose tolerance test (OGTTs), and the mean follow-up duration was 27 years. Regression analyses were carried out for indices of glucose metabolism in relation to quintiles (Q1-Q5) of total aliponectin levels. After stratification for smoking or not, the association between total adiponectin and the first incidence of fatal or non-fatal cardiovascular disease (CVD) was analyzed, using Cox's proportional-hazards regression model.

Results. In a separate multiple-regression analysis and after adjusting for possible confounders, the relationship between adiponectin levels and markers of glucose metabolism were found to be significant (P<0.05). However, adiponectin did not independently predict the risk of stroke, coronary events, or a combination of these two outcomes.

Conclusion. Levels of total plasma adiponectin are not useful for predicting long-term cardiovascular events in middle-aged men, but are strongly associated with glucose metabolism and markers of insulin resistance. (c) 2010 Elsevier Masson SAS. All rights reserved.

Place, publisher, year, edition, pages
2010. Vol. 36, no 2, p. 137-143
Keywords [en]
Adiponectin, Cardiovascular events, Coronary events, Glucose metabolism, Stroke, Prospective study, Long-term
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-26692DOI: 10.1016/j.diabet.2009.10.004ISI: 000277835800007OAI: oai:DiVA.org:oru-26692DiVA, id: diva2:578301
Note

Payam Khalili  is also affiliated to Cent Hosp Karlstad, Dept Internal Med, S-65230 Karlstad, Sweden

J. Jendle is also affiliated to Cent Hosp Karlstad, Dept Internal Med, S-65230 Karlstad, Sweden

Peter M. Nilsson is also affiliated to  Lund Univ, Malmo Univ Hosp, Dept Clin Sci, Malmo, Sweden

Available from: 2012-12-18 Created: 2012-12-18 Last updated: 2018-09-14Bibliographically approved
In thesis
1. Risk factors for cardiovascular events and incident hospital-treated diabetes in the population
Open this publication in new window or tab >>Risk factors for cardiovascular events and incident hospital-treated diabetes in the population
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Background: Cardiovascular disease (CVD) is the leading cause of death worldwide. Well-established risk factors for CVD include increasing age, male sex, sedentary lifestyle, obesity, smoking, diabetes, hypertension, dyslipidaemia and low socio-economic status. Traditional risk factors do, however, not fully explain cardiovascular risk in general. In this thesis we focused on two conventional risk factors (smoking, blood pressure), and two unconventional risk markers (adiponectin, an adipocyte derived protein; and sialic acid (SA), a marker of systemic inflammation) for prediction of CVD events.

Aims: In Paper I we examined to what degree smoking habits modify the risk of CVD in relation to systolic blood pressure levels in middle-aged men. In Paper II we investigated the predictive role of adiponectin for risk of CVD as well as the cross-sectional associations between adiponectin and markers of glucose metabolism, also in men. In Paper III we examined if increasing pulse pressure (PP) and increasing levels of SA both increase the risk of CVD and whether their effects act in synergism. In Paper IV the association of SA with risk of incident diabetes mellitus and related complications, resulting in hospitalization, was studied.

Subjects and Methods: Two large-scale, population-based, screening studies with long follow-up periods have been used. The Malmö Preventive Project (MPP) was used with 22,444 individuals in Paper I and a sub cohort of 3,885 individuals in Paper II. The Värmland Health Survey (VHS) was used in Papers III and IV with 37,843 and 87,035 individuals, respectively.

Results: CVD risk increases with increasing systolic blood pressure levels and this risk is almost doubled in smokers. Total adiponectin level is not associated with increased risk of future CVD but it is inversely associated with markers of glucose metabolism. PP and SA both contribute to risk of future CVD. Adjustment for mean arterial pressure reduces the risk induced by PP. Elevated SA contributes to increased risk of incident diabetes and related complications leading to hospitalization.

Place, publisher, year, edition, pages
Örebro: Örebro universitet, 2012. p. 73
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 79
Keywords
Adiponectin, blood pressure, cardiovascular risk, diabetes, inflammation, pulse pressure, sialic acid, smoking
National Category
Medical and Health Sciences Cardiac and Cardiovascular Systems
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-24173 (URN)978-91-7668-905-9 (ISBN)
Public defence
2012-12-14, Hörsal P1, Prismahuset, Örebro universitet, Fakultetsgatan 1, Örebro, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2012-07-30 Created: 2012-07-30 Last updated: 2017-10-17Bibliographically approved

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