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Blood concentrations of homocysteine and methylmalonic acid among demented and non-demented Swedish elderly with and without home care services and vitamin B(12) prescriptions
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Geriatric Medicine,, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.ORCID iD: 0000-0002-2869-7239
Department of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
Department of Pharmacology and Clinical Neuroscience, Division of Clinical Pharmacology, University Hospital of Northern Sweden, Umeå, Sweden.
Department of Laboratory Medicine, Division of Clinical Chemistry, Örebro University Hospital, Örebro, Sweden.
2012 (English)In: Dementia and geriatric cognitive disorders extra, E-ISSN 1664-5464, Vol. 2, no 1, p. 387-399Article in journal (Refereed) Published
Abstract [en]

Background and Aims: Total plasma homocysteine (tHcy) has been suggested as a risk factor of dementia. Our aim was to investigate potential differences in tHcy status in relation to the prescription of vitamin B(12) and dementia diagnosis. We examined whether vitamin B(12) prescriptions, a family history of dementia, or the need for home care service might be associated with tHcy values.

Methods: A cross-sectional monocenter study comprising 926 consecutive subjects attending our Memory Care Unit was conducted.

Results: Demented subjects being prescribed vitamin B(12) had higher serum vitamin B(12) (p = 0.025) but also higher tHcy (p < 0.001) and serum methylmalonate (p = 0.032), and lower serum folate (p < 0.001) than those who did not receive vitamin B(12) prescriptions. tHcy levels were significantly higher in non-demented subjects receiving home care service (p = 0.007). This group also had lower serum albumin (dementia: p < 0.001; non-dementia: p = 0.004). There was no difference in renal function (estimated glomerular filtration rate) in demented or non-demented subjects with or without vitamin B(12) prescriptions (dementia with/without vitamin B(12) prescription: p = 0.561; non-dementia with/without vitamin B(12) prescription: p = 0.710).

Conclusion: Despite vitamin B(12) prescriptions, demented subjects had higher tHcy and methylmalonate values. The elevated metabolite values could not be explained by differences in renal function. Thus, elderly subjects on vitamin B(12) prescription appear to have unmet nutritional needs.

Place, publisher, year, edition, pages
Basel, Switzerland: S. Karger, 2012. Vol. 2, no 1, p. 387-399
Keywords [en]
Homocysteine, dementia, vitamin B12, folate, home care service
National Category
Geriatrics
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-27348DOI: 10.1159/000339669PubMedID: 23277779OAI: oai:DiVA.org:oru-27348DiVA, id: diva2:603485
Available from: 2013-02-06 Created: 2013-02-06 Last updated: 2019-04-15Bibliographically approved

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Hagnelius, Nils-OlofNilsson, Torbjörn K.

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