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Protein markers for the differential diagnosis of vascular dementia and Alzheimer's disease
Memory Disorders Research Group Section 6702, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Köpenhamn, Denmark.
Department of Geriatric Medicine, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0002-2869-7239
Memory Disorders Research Group Section 6702, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Köpenhamn, Denmark.
Department of Laboratory Chemistry, Örebro University Hospital, Örebro, Sweden.
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2012 (English)In: International Journal of Proteomics, ISSN 2090-2166, E-ISSN 2090-2174, Vol. 2012, article id 824024Article in journal (Refereed) Published
Abstract [en]

Alzheimer's disease (AD) is the most common form of dementia found in all human populations worldwide, while vascular dementia (VaD) is the second most common form of dementia. New biomarkers for early and specific diagnosis of AD and VaD are needed to achieve greater insight into changes occurring in the brain and direct therapeutic strategies. The objective of this explorative study was to discover candidate protein biomarkers for the differential diagnosis between VaD and AD. Surface-enhanced laser desorption/ionization (SELDI) TOF-MS was used to differentially profile proteins and peptides in CSF samples from 28 AD patients and 21 patients with VaD. A combination of univariate (Kruskal-Wallis) and multivariate (independent component analysis) statistical approaches produced a list of 27 proteins and peptides that could differentiate between VaD and AD. These markers represent various physiological processes, such as protein degradation (ubiquitin), protease inhibition (cystatin C and alpha-1-antichymoptrypsin), and inflammation (C3a and C4a) that are known to be represented in neurodegenerative diseases.

Place, publisher, year, edition, pages
New York, USA: Hindawi Publishing Corporation, 2012. Vol. 2012, article id 824024
National Category
Geriatrics
Research subject
Medicine
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URN: urn:nbn:se:oru:diva-27346DOI: 10.1155/2012/824024PubMedID: 22701795OAI: oai:DiVA.org:oru-27346DiVA, id: diva2:603488
Available from: 2013-02-06 Created: 2013-02-06 Last updated: 2017-12-06Bibliographically approved

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Hagnelius, Nils-Olof

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