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Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients
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2012 (English)In: Genes and Immunity, ISSN 1466-4879, E-ISSN 1476-5470, Vol. 13, no 6, p. 474-480Article in journal (Refereed) Published
Abstract [en]

Some genetic loci may affect susceptibility to multiple immune system-related diseases. In the current study, we investigated whether the known susceptibility loci for celiac disease (CelD) also associate with Crohn's disease (CD) and/or ulcerative colitis (UC), the two main forms of inflammatory bowel disease (IBD), in Finnish patients. A total of 45 genetic markers were genotyped in a Finnish data set comprising 699 IBD patients and 2482 controls. Single-marker association with IBD and its subphenotypes was tested. A meta-analysis with a Swedish UC data set was also performed. A total of 12 single-nucleotide polymorphisms associated with CD and/or UC (P<0.05). In the subphenotype analysis, rs6974491-ELMO1 (P=0.0002, odds ratio (OR): 2.20) and rs2298428-UBE2L3 (P=5.44 × 10(-5), OR: 2.59) associated with pediatric UC and CD, respectively. In the meta-analysis, rs4819388-ICOSLG (P=0.00042, OR: 0.79) associated with UC. In the subphenotype meta-analysis, rs1738074-TAGAP (P=7.40 × 10(-5), OR: 0.61), rs6974491-ELMO1 (P=0.00052, OR: 1.73) and rs4819388-ICOSLG (P=0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively. Multiple CelD risk loci also confer susceptibility for CD and/or UC in the Finnish and Swedish populations. Certain genetic risk variants may furthermore predispose an individual for developing a particular disease phenotype.

Place, publisher, year, edition, pages
Nature Publishing Group, 2012. Vol. 13, no 6, p. 474-480
Keywords [en]
celiac disease; Crohn's disease; ulcerative colitis; association
National Category
Immunology in the medical area Medical Genetics
Research subject
Immunology; Genetics
Identifiers
URN: urn:nbn:se:oru:diva-27419DOI: 10.1038/gene.2012.21ISI: 000308455000006PubMedID: 22592522Scopus ID: 2-s2.0-84865634437OAI: oai:DiVA.org:oru-27419DiVA, id: diva2:603690
Funder
Swedish Research Council
Note

Funding Agencies:

Academy of Finland, Biocentrum Helsinki

Special State Subsidy for Health Sciences (EVO)

Research Program of Molecular Medicine at University of Helsinki

Academy of Finland 129322  139635

Bengt Ihre's Foundation

Örebro University Hospital Research foundation

Available from: 2013-02-06 Created: 2013-02-06 Last updated: 2018-01-11Bibliographically approved

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Halfvarson, Jonas

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