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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Wellcome Trust Genome Campus Hinxton, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0003-0122-7234
Inflammatory Bowel Diseases, Queensland Institute of Medical Research, Brisbane, Australia.
Number of Authors: 1132011 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 43, no 3, p. 246-252Article in journal (Refereed) Published
Abstract [en]

Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.

Place, publisher, year, edition, pages
2011. Vol. 43, no 3, p. 246-252
National Category
Clinical Medicine
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-27407DOI: 10.1038/ng.764ISI: 000287693800016PubMedID: 21297633Scopus ID: 2-s2.0-79952195585OAI: oai:DiVA.org:oru-27407DiVA, id: diva2:603711
Available from: 2013-02-06 Created: 2013-02-06 Last updated: 2018-05-05Bibliographically approved

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CiteExportLink to record
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