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Individualized estimation of the benefit of radical prostatectomy from the Scandinavian prostate cancer group randomized trial
Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York NY, United States.
Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle WA, United States.
Karolinska Institute, Stockholm, Sweden.
Harvard School of Public Health, Boston MA, United States.
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2012 (English)In: European Urology, ISSN 0302-2838, E-ISSN 1873-7560, Vol. 62, no 2, p. 204-209Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Although there is randomized evidence that radical prostatectomy improves survival, there are few data on how benefit varies by baseline risk.

OBJECTIVE: We aimed to create a statistical model to calculate the decrease in risk of death associated with surgery for an individual patient, using stage, grade, prostate-specific antigen, and age as predictors.

DESIGN, SETTING, AND PARTICIPANTS: A total of 695 men with T1 or T2 prostate cancer participated in the Scandinavian Prostate Cancer Group 4 trial (SPCG-4).

INTERVENTION: Patients in SPCG-4 were randomized to radical prostatectomy or conservative management. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Competing risk models were created separately for the radical prostatectomy and the watchful waiting group, with the difference between model predictions constituting the estimated benefit for an individual patient.

RESULTS AND LIMITATIONS: Individualized predictions of surgery benefit varied widely depending on age and tumor characteristics. At 65 yr of age, the absolute 10-yr risk reduction in prostate cancer mortality attributable to radical prostatectomy ranged from 4.5% to 17.2% for low- versus high-risk patients. Little expected benefit was associated with surgery much beyond age 70. Only about a quarter of men had an individualized benefit within even 50% of the mean. A limitation is that estimates from SPCG-4 have to be applied cautiously to contemporary patients.

CONCLUSIONS: Our model suggests that it is hard to justify surgery in patients with Gleason 6, T1 disease or in those patients much above 70 yr of age. Conversely, surgery seems unequivocally of benefit for patients who have Gleason 8, or Gleason 7, stage T2. For patients with Gleason 6 T2 and Gleason 7 T1, treatment is more of a judgment call, depending on patient preference and other clinical findings, such as the number of positive biopsy cores and comorbidities.

Place, publisher, year, edition, pages
2012. Vol. 62, no 2, p. 204-209
Keywords [en]
Prostatic neoplasms; Statistics and research design; Randomized controlled trial; Prostatectomy
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:oru:diva-27454DOI: 10.1016/j.eururo.2012.04.024ISI: 000305841100014PubMedID: 22541389Scopus ID: 2-s2.0-84862877628OAI: oai:DiVA.org:oru-27454DiVA, id: diva2:603762
Funder
Swedish Cancer Society, 07 0512
Note

Funding Agencies:

National Institutes of Health in the United States 1RO1 CA 108746-01A1

Prostate Cancer Foundation

Sidney Kimmel Center for Prostate and Urologic Cancers

National Cancer Institute P50-CA92629

Available from: 2013-02-06 Created: 2013-02-06 Last updated: 2018-05-12Bibliographically approved

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Johansson, J. E.

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