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Rye bread consumption in early life and reduced risk of advanced prostate cancer
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2012 (English)In: Cancer Causes and Control, ISSN 0957-5243, E-ISSN 1573-7225, Vol. 23, no 6, p. 941-950Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To determine whether consumption of whole-grain rye bread, oatmeal, and whole-wheat bread, during different periods of life, is associated with risk of prostate cancer (PCa).

METHODS: From 2002 to 2006, 2,268 men, aged 67-96 years, reported their dietary habits in the AGES-Reykjavik cohort study. Dietary habits were assessed for early life, midlife, and current life using a validated food frequency questionnaire. Through linkage to cancer and mortality registers, we retrieved information on PCa diagnosis and mortality through 2009. We used regression models to estimate odds ratios (ORs) and hazard ratios (HRs) for PCa according to whole-grain consumption, adjusted for possible confounding factors including fish, fish liver oil, meat, and milk intake.

RESULTS: Of the 2,268 men, 347 had or were diagnosed with PCa during follow-up, 63 with advanced disease (stage 3+ or died of PCa). Daily rye bread consumption in adolescence (vs. less than daily) was associated with a decreased risk of PCa diagnosis (OR = 0.76, 95 % confidence interval (CI): 0.59-0.98) and of advanced PCa (OR = 0.47, 95 % CI: 0.27-0.84). High intake of oatmeal in adolescence (≥5 vs. ≤4 times/week) was not significantly associated with risk of PCa diagnosis (OR = 0.99, 95 % CI: 0.77-1.27) nor advanced PCa (OR = 0.67, 95 % CI: 0.37-1.20). Midlife and late life consumption of rye bread, oatmeal, or whole-wheat bread was not associated with PCa risk.

CONCLUSION: Our results suggest that rye bread consumption in adolescence may be associated with reduced risk of PCa, particularly advanced disease.

Place, publisher, year, edition, pages
Springer, 2012. Vol. 23, no 6, p. 941-950
Keywords [en]
Adolescent; Diet; Epidemiology; Rye bread; Prostatic neoplasms; Whole grain; AGES-Reykjavik study
National Category
Cancer and Oncology Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:oru:diva-27797DOI: 10.1007/s10552-012-9965-2ISI: 000304105700015PubMedID: 22527172Scopus ID: 2-s2.0-84862499459OAI: oai:DiVA.org:oru-27797DiVA, id: diva2:608782
Note

Funding Agencies:

Framfor (Progress), an Icelandic organization

HELGA

NIH 5 T32 CA09001-36

American Institute for Cancer Research

National Institute on Aging N01-AG-1-2100

National Institute on Aging

Icelandic Heart Association

Althingi (the Icelandic Parliament)

Framfor

Available from: 2013-03-01 Created: 2013-03-01 Last updated: 2018-05-12Bibliographically approved

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Fall, Katja

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School of Health and Medical Sciences, Örebro University, Sweden
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