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Clinical COPD questionnaire score (CCQ) and mortality
Department of Respiratory Medicine, Örebro University Hospital, Örebro, Sweden.
Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden.
Department of Public Health and Caring Science, Family Medicine and Clinical Epidemiology, Uppsala University, Uppsala, Sweden.
Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden; Department of Primary Care and Public Health, Charing Cross Hospital, Imperial College, London, United Kingdom. (Clinical Epidemiology and Biostatistics)ORCID iD: 0000-0001-6328-5494
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2012 (English)In: The International Journal of Chronic Obstructive Pulmonary Disease, ISSN 1176-9106, E-ISSN 1178-2005, Vol. 7, p. 833-842Article in journal (Refereed) Published
Abstract [en]

Introduction: The Clinical COPD Questionnaire (CCQ) measures health status and can be used to assess health-related quality of life (HRQL). We investigated whether CCQ is also associated with mortality.

Methods: Some 1111 Swedish primary and secondary care chronic obstructive pulmonary disease (COPD) patients were randomly selected. Information from questionnaires and medical record review were obtained in 970 patients. The Swedish Board of Health and Welfare provided mortality data. Cox regression estimated survival, with adjustment for age, sex, heart disease, and lung function (for a subset with spirometry data, n = 530). Age and sex-standardized mortality ratios were calculated.

Results: Over 5 years, 220 patients (22.7%) died. Mortality risk was higher for mean CCQ ≥ 3 (37.8% died) compared with mean CCQ < 1 (11.4%), producing an adjusted hazard ratio (HR) (and 95% confidence interval [CI]) of 3.13 (1.98 to 4.95). After further adjustment for 1 second forced expiratory volume (expressed as percent of the European Community for Steel and Coal reference values ), the association remained (HR 2.94 [1.42 to 6.10]). The mortality risk was higher than in the general population, with standardized mortality ratio (and 95% CI) of 1.87 (1.18 to 2.80) with CCQ < 1, increasing to 6.05 (4.94 to 7.44) with CCQ ≥ 3.

Conclusion: CCQ is predictive of mortality in COPD patients. As HRQL and mortality are both important clinical endpoints, CCQ could be used to target interventions.

Place, publisher, year, edition, pages
Auckland, New Zealand: Dove Medical Press , 2012. Vol. 7, p. 833-842
Keywords [en]
Health status, health related quality of life (HRQL), standardized mortality ratios (SMR)
National Category
Medical and Health Sciences Respiratory Medicine and Allergy
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-27815DOI: 10.2147/COPD.S38119ISI: 000319053100086PubMedID: 23277739Scopus ID: 2-s2.0-84872318445OAI: oai:DiVA.org:oru-27815DiVA, id: diva2:608817
Available from: 2013-03-01 Created: 2013-03-01 Last updated: 2018-07-22Bibliographically approved

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Sundh, JosefinMontgomery, Scott M.

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