oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans
Örebro University, School of Science and Technology. (MTM)ORCID iD: 0000-0003-3722-4633
Örebro University, School of Science and Technology. (MTM)
Örebro University, School of Science and Technology. (MTM)
Örebro University, School of Science and Technology. (MTM)ORCID iD: 0000-0001-6217-8857
Show others and affiliations
2013 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 51, p. 8-12Article in journal (Refereed) Published
Abstract [en]

Levels of perfluorocarboxylates (PFCAs) in biological compartments have been known for some time but their transport routes and distribution patterns are not properly elucidated. The opinions diverge whether the exposure of the general population occurs indirect through precursors or direct via PFCAs. Previous results showed that ski wax technicians are exposed to levels up to 92 000 ng/m(3) of 8:2 fluorotelomer alcohol (FTOH) via air and have elevated blood levels of PFCAs. Blood samples were collected in 2007-2011 and analyzed for C(4)-C(18) PFCAs, 6:2, 8:2 and 10:2 unsaturated fluorotelomer acids (FTUCAs) and 3:3, 5:3 and 7:3 fluorotelomer acids (FTCAs) using UPLC-MS/MS. Perfluorooctanoic acid (PFOA) was detected in levels ranging from 1.90 to 628 ng/mL whole blood (wb). Metabolic intermediates 5:3 and 7:3 FTCA were detected in all samples at levels up to 6.1 and 3.9 ng/mL wb. 6:2, 8:2 and 10:2 FTUCAs showed maximum levels of 0.07, 0.64 and 0.11 ng/mL wb. Also, for the first time levels of PFHxDA and PFOcDA were detected in the human blood at mean concentrations up to 4.22 ng/mL wb and 4.25 ng/mL wb respectively. The aim of this study was to determine concentrations of PFCAs and FTOH metabolites in blood from ski wax technicians.

Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 51, p. 8-12
National Category
Chemical Sciences Biological Sciences Environmental Sciences
Research subject
Chemistry; Environmental Chemistry; Biology
Identifiers
URN: urn:nbn:se:oru:diva-28803DOI: 10.1016/j.envint.2012.09.001ISI: 000314618100002PubMedID: 23138016Scopus ID: 2-s2.0-84868330094OAI: oai:DiVA.org:oru-28803DiVA, id: diva2:617883
Note

Funding agency: Cancer and Allergy Foundation 

Available from: 2013-04-24 Created: 2013-04-24 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Nilsson, HelenaKärrman, AnnaRotander, Annavan Bavel, BertLindström, GunillaWestberg, Håkan

Search in DiVA

By author/editor
Nilsson, HelenaKärrman, AnnaRotander, Annavan Bavel, BertLindström, GunillaWestberg, Håkan
By organisation
School of Science and TechnologyÖrebro University Hospital
In the same journal
Environment International
Chemical SciencesBiological SciencesEnvironmental Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 429 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf