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An environmental wide association study (EWAS) approach to the metabolic syndrome
Örebro University, School of Science and Technology.ORCID iD: 0000-0001-5752-4196
Örebro University, School of Science and Technology.ORCID iD: 0000-0001-6217-8857
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2013 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 55, p. 1-8Article in journal (Refereed) Published
Abstract [en]

Background

Environmental contaminants have previously been linked to components of the Metabolic Syndrome (MetS). However, exposure to environmental contaminants is in part determined by various lifestyle factors.

Objective

Using an "Environmental Wide Association Study" (ELWAS) integrating environmental contaminants and lifestyle factors, we aimed to evaluate a possible additive role of both contaminants and lifestyle factors regarding MetS.

Methods

1016 subjects aged 70 years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. 43 environmental contaminants were measured in the circulation. Dietary records were used to evaluate 21 nutrients and the proportions of 13 fatty acids were determined in serum cholesterol esters to further quantify fat quality intake. Adding 5 other important lifestyle factors yielded together 76 environmental and lifestyle factors. MetS was defined by the NCEP/ATPIII-criteria.

Results

23% had MetS. Using cross-validation within the sample, fourteen environmental contaminants or lifestyle factors consistently showed a false discovery rate <0.05. When the major variables entered a multiple model, only p,p'-DDE levels (positive), PCB209 (inverse) and exercise habits (inverse) were together with a fatty acid pattern, with high levels of palmitic acid and oleic acid and low levels of linoleic acid, related to MetS (p<0.002 for all variables).

Conclusion

Using a cross-sectional EWAS approach, certain environmental contaminants and lifestyle factors were found to be associated with prevalent metabolic syndrome in an additive fashion in an elderly population.

Place, publisher, year, edition, pages
2013. Vol. 55, p. 1-8
Keywords [en]
Metabolic syndrome, Lifestyle factors, Environmental contaminants, Fatty acids, Exercise habits, Dietary records
National Category
Chemical Sciences
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-29390DOI: 10.1016/j.envint.2013.01.017ISI: 000318261900001OAI: oai:DiVA.org:oru-29390DiVA, id: diva2:626902
Available from: 2013-06-10 Created: 2013-06-10 Last updated: 2017-12-06Bibliographically approved

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Salihovic, Samiravan Bavel, Bert

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