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Down syndrome is associated with elevated risk of celiac disease: a nationwide case-control study
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Astrid Lindgren Children's Hospital, Solna, Sweden.
Clinical Epidemiology Unit, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden; Karolinska Institute, Stockholm, Sweden.
Astrid Lindgren Children's Hospital, Solna, Sweden.
Clinical Epidemiology Unit, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden; Karolinska Institute, Stockholm, Sweden.
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2013 (English)In: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 163, no 1, p. 237-242Article in journal (Refereed) Published
Abstract [en]

Objective: To provide risk estimates for celiac disease (CD) in Down syndrome (DS) compared with the general population.

Study design: In this nationwide Swedish case-control study, we examined the risk of CD in individuals with DS born between 1973 and 2008. Study participants consisted of 2 populations: 11 749 patients with biopsy-verified CD (villous atrophy [VA], equivalent to Marsh grade III) who were identified through histopathology reports from the 28 pathology departments in Sweden and 53 887 population-based controls matched for sex, age, calendar year of birth, and county of residence. We used prospectively recorded data from Swedish health registers to identify individuals with DS. ORs were calculated using conditional logistic regression.

Results: Of the 11 749 individuals with CD, 165 had a diagnosis of DS (1.4%) compared with 55/53 887 controls (0.1%). This corresponded to an OR of 6.15 (95% CI = 5.09-7.43) for subsequent CD in individuals with DS compared with the general population. The association between DS and CD was not affected by maternal age at delivery, infant sex, or presence of type 1 diabetes mellitus in the child.

Conclusions: We found a sixfold increased risk of CD in individuals with DS. This study adds precision to the previously reported association between DS and CD.

Place, publisher, year, edition, pages
2013. Vol. 163, no 1, p. 237-242
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-30198DOI: 10.1016/j.jpeds.2012.12.087ISI: 000321494000047PubMedID: 23399451OAI: oai:DiVA.org:oru-30198DiVA, id: diva2:640302
Available from: 2013-08-13 Created: 2013-08-13 Last updated: 2018-09-11Bibliographically approved

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Mårild, KarlLudvigsson, Jonas F.

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School of Health and Medical Sciences, Örebro University, SwedenÖrebro University Hospital
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