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Cancer morbidity and quartz exposure in Swedish iron foundries
Örebro University, School of Science and Technology. Örebro University Hospital. (Människa-Teknik-Miljö (MTM))
Örebro University, School of Science and Technology. (Människa-Teknik-Miljö (MTM))
Swedish Institute for Infectious Disease ControlSolnaSweden.
Department of Clinical Medicines, Örebro University, Örebro, Sweden.
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2013 (English)In: International Archives of Occupational and Environmental Health, ISSN 0340-0131, E-ISSN 1432-1246, Vol. 86, no 5, p. 499-507Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to determine cancer morbidity amongst Swedish iron foundry workers with special reference to quartz exposure. In addition to respirable dust and quartz, phenol, formaldehyde, furfuryl alcohols, polycyclic aromatic hydrocarbons (PAHs), carbon black, isocyanates and asbestos are used or generated by foundry production techniques and exposure to any of these substances could have potentially carcinogenic effects. Cancer morbidity between 1958 and 2004 was evaluated in a cohort of 3,045 male foundry workers employed for > 1 year between 1913 and 2005. Standardised incidence ratios (SIRs) with 95 % confidence intervals (95 % CI) were determined by comparing observed numbers of incident cancers with frequencies in the Swedish cancer register. Exposure measures were assessed using information from the personal files of employees and modelling quartz measurement based on a database of 1,667 quartz measurements. Dose responses for lung cancer were determined for duration of employment and cumulative quartz exposure for latency periods > 20 years. Overall cancer morbidity was not increased amongst the foundry workers (SIR 1.00; 95 % CI, 0.90-1.11), but the incidence of lung cancer was significantly elevated (SIR 1.61; 95 % CI, 1.20-2.12). A non-significant negative dose response was determined using external comparison with a latency period of > 20 years (SIR 2.05, 1.72 1.26 for the low, medium and high exposure groups), supported by internal comparison data (hazard ratios 1, 1.01, 0.78) for the corresponding groups. For cancers at sites with at least five observed cases and a SIR > 1.25, non-significant risks with SIRs > 1.5 were determined for cancers of the liver, larynx, testis, connective muscle tissue, multiple myeloma plasmacytoma and lymphatic leukaemia. A significant overall risk of lung cancer was determined, but using external and internal comparison groups could not confirm any dose response at our cumulative quartz dose levels.

Place, publisher, year, edition, pages
2013. Vol. 86, no 5, p. 499-507
Keywords [en]
Cohort study, Lung cancer, Occupational exposure, Respirable silica, Smoking habits
National Category
Medical and Health Sciences Occupational Health and Environmental Health
Research subject
Occupational and Environmental Medicine
Identifiers
URN: urn:nbn:se:oru:diva-30184DOI: 10.1007/s00420-012-0782-4ISI: 000320394300001OAI: oai:DiVA.org:oru-30184DiVA, id: diva2:640386
Available from: 2013-08-13 Created: 2013-08-13 Last updated: 2018-05-19Bibliographically approved

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Westberg, HåkanOhlson, Carl-Göran

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Westberg, HåkanAndersson, LenaOhlson, Carl-Göran
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School of Science and TechnologyÖrebro University HospitalSchool of Health and Medical Sciences, Örebro University, Sweden
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International Archives of Occupational and Environmental Health
Medical and Health SciencesOccupational Health and Environmental Health

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