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Polymorphism in the retinoic acid metabolizing enzyme CYP26B1 and the development of Crohn's disease
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.ORCID iD: 0000-0002-9826-0462
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
Örebro University Hospital, Örebro, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
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2013 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, no 8, p. e72739-Article in journal (Refereed) Published
Abstract [en]

Several studies suggest that Vitamin A may be involved in the pathogenesis of inflammatory bowel disease (IBD), but the mechanism is still unknown. Cytochrome P450 26 B1 (CYP26B1) is involved in the degradation of retinoic acid and the polymorphism rs2241057 has an elevated catabolic function of retinoic acid, why we hypothesized that the rs2241057 polymorphism may affect the risk of Crohn's disease (CD) and Ulcerative Colitis (UC). DNA from 1378 IBD patients, divided into 871 patients with CD and 507 with UC, and 1205 healthy controls collected at Örebro University Hospital and Karolinska University Hospital were analyzed for the CYP26B1 rs2241057 polymorphism with TaqMan® SNP Genotyping Assay followed by allelic discrimination analysis. A higher frequency of patients homozygous for the major (T) allele was associated with CD but not UC compared to the frequency found in healthy controls. A significant association between the major allele and non-stricturing, non-penetrating phenotype was evident for CD. However, the observed associations reached borderline significance only, after correcting for multiple testing. We suggest that homozygous carriers of the major (T) allele, relative to homozygous carriers of the minor (C) allele, of the CYP26B1 polymorphism rs2241057 may have an increased risk for the development of CD, which possibly may be due to elevated levels of retinoic acid. Our data may support the role of Vitamin A in the pathophysiology of CD, but the exact mechanisms remain to be elucidated.

Place, publisher, year, edition, pages
2013. Vol. 8, no 8, p. e72739-
National Category
Medical Genetics
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-30844DOI: 10.1371/journal.pone.0072739ISI: 000323425700188PubMedID: 23977348Scopus ID: 2-s2.0-84907505415OAI: oai:DiVA.org:oru-30844DiVA, id: diva2:649186
Funder
Swedish Research Council
Note

Funding agency:

Örebro University 

Bengt Ihre's foundation 

Nanna Svartz' foundation 

Orebro University Hospital Research Foundation 

Orebro County Research Foundation 

Swedish Foundation for Gastrointestinal research

Available from: 2013-09-17 Created: 2013-09-17 Last updated: 2018-05-21Bibliographically approved

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Fransén, KarinElmabsout, AliNyhlin, NilsWickbom, AnnaBohr, JohanTysk, CurtSirsjö, AllanHalfvarson, Jonas

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Fransén, KarinElmabsout, AliNyhlin, NilsWickbom, AnnaBohr, JohanTysk, CurtSirsjö, AllanHalfvarson, Jonas
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School of Health and Medical Sciences, Örebro University, SwedenÖrebro University HospitalSchool of Medicine, Örebro University, Sweden
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