oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A double-blind dose-finding study of local anesthetics infused intraperitoneally for postoperative pain relief following abdominal hysterectomy.
Department of Anesthesiology and Intensive Care, University Hospital, Örebro.
Department of Anesthesiology and Intensive Care, University Hospital, Örebro; Linköping University, Linköping, Sweden.ORCID iD: 0000-0001-6128-7752
Department of Obstetrics and Gynecology, University Hospital, Örebro.
Department of Anesthesiology and Intensive Care, University Hospital, Örebro.
Show others and affiliations
2009 (English)In: European Journal of Anaesthesiology, ISSN 0265-0215, E-ISSN 1365-2346, Vol. 26, p. 421-429Article in journal (Refereed) Published
Abstract [en]

Background and objective Local anaesthetics administered intraabdominally have been found to reduce analgesic requirements postoperatively after hysterectomy. This study was designed to assess the optimal dose of local anaesthetics for best pain relief.

Methods Sixty patients undergoing abdominal hysterectomy were randomly divided into three groups to receive 10 ml hS1 infusion of levobupivacaine intraabdominally postoperatively for 48 h in a double-blind manner: group L, 7.5mghS1; group M, 12.5mghS1 and group H, 17.5mghS1. Pain intensity was measured using the numeric rating scale, ketobemidone consumption over 48 h was measured with a patient controlled analgesia pump, recovery parameters, expiratory muscle strength, time to home readiness, plasma concentration of levobupivacaine and health-related quality of life were all measured at defined time points postoperatively.

Results No differences were found between the active groups in pain intensity, recovery parameters or healthrelated quality of life. Pain intensity was maximal during 0– 4 h and during coughing. Expiratory muscle strength decreased significantly during 0–4 h in all active groups, with no differences between the groups. Plasma concentration of levobupivacaine was below known toxic concentrations in humans, and no patient had symptoms of local anaesthetic toxicity. Health-related quality of life showed improved scores at 3 months after the operation compared with preoperative values, but no differences between the groups were found in any of the parameters. Conclusion Satisfactory analgesia can be achieved with low doses of levobupivacaine administered intraabdominally, except during the early postoperative period. No advantages were seen in this study when higher doses of levobupivacaine were administered as a continuous infusion for postoperative pain relief. Eur J Anaesthesiol 26:421–429 Q 2009 European Society of Anaesthesiology

Place, publisher, year, edition, pages
2009. Vol. 26, p. 421-429
Keywords [en]
abdominal hysterectomy, local anaesthetics, opiates, postoperative
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-32069OAI: oai:DiVA.org:oru-32069DiVA, id: diva2:657356
Note

The title in EJA 2009,26:421-429 is somewhat changed and the wrong authors are noted in the summary

"Intraabdominal local anaesthetics for postoperative pain relief following abdominal hysterectomy: a randomized, double-blind, dose-finding study"

Available from: 2013-10-18 Created: 2013-10-18 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

No full text in DiVA

Authority records BETA

Perniola, AndreaGupta, AnilDarvish, BijanAxelsson, Kjell

Search in DiVA

By author/editor
Perniola, AndreaGupta, AnilCrafoord, KristinaDarvish, BijanAxelsson, Kjell
In the same journal
European Journal of Anaesthesiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 35 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf