oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Oral delivery of plant-derived HIV-1 p24 antigen in low doses shows a superior priming effect in mice compared to high doses
Örebro University, School of Science and Technology. Örebro Life Sci Ctr, Univ Örebro, Örebro, Sweden; Sch Sci & Technol, Univ Örebro, Örebro, Sweden.
Swedish Institute for Communicable Disease Control (SMI), Stockholm, Sweden.
Dept Microbiol Tumor & Cell Biol, Karolinska Inst, Stockholm, Sweden.
Örebro University, School of Science and Technology. Örebro Life Sci Ctr, Univ Örebro, Örebro, Sweden. (Biokemi)
Show others and affiliations
2014 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 32, no 20, p. 2288-2293Article in journal (Refereed) Published
Abstract [en]

During early infection with human immunodeficiency virus type 1 (HIV-1), there is a rapid depletion of CD4+ T-cells in the gut-associated lymphoid tissue (GALT) in the gastrointestinal tract. Therefore, immediate protection at these surfaces is of high priority for the development of an HIV-1 vaccine. Thus, transgenic plants expressing HIV-1 antigens, which are exposed to immune competent cells in the GALT during oral administration, can be interesting as potential vaccine candidates. In the present study, we used two HIV-1 p24 antigen-expressing transgenic plant systems, Arabidopsis thaliana and Daucus carota, in oral immunization experiments. Both transgenic plant systems showed a priming effect in mice and induced humoral immune responses, which could be detected as anti-p24-specific IgG in sera after an intramuscular p24 protein boost. Dose-dependent antigen analyses using transgenic Arabidopsis thaliana indicated that low p24 antigen doses were superior to high p24 antigen doses

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 32, no 20, p. 2288-2293
Keywords [en]
Transgenic plants; Arabidopsis thaliana; Carrot; Edible vaccine; Oral immunization; HIV-1 p24
National Category
Immunology in the medical area Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Biochemistry and Molecular Biology
Research subject
Biochemistry; Immunology
Identifiers
URN: urn:nbn:se:oru:diva-33982DOI: 10.1016/j.vaccine.2014.02.073ISI: 000335100600005PubMedID: 24631072Scopus ID: 2-s2.0-84897502968OAI: oai:DiVA.org:oru-33982DiVA, id: diva2:699465
Projects
Ätbara vacciner
Funder
Knowledge Foundation
Note

Funding Agencies:

Örebro University's Faculty for Business, Science, and Technology 

Nyckelfonden

Available from: 2014-02-27 Created: 2014-02-27 Last updated: 2018-06-05Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Lindh, IngridHadad, RonzaKalbina, IrinaStrid, ÅkeAndersson, Sören

Search in DiVA

By author/editor
Lindh, IngridHadad, RonzaKalbina, IrinaStrid, ÅkeAndersson, Sören
By organisation
School of Science and TechnologyÖrebro University Hospital
In the same journal
Vaccine
Immunology in the medical areaMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 408 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf