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Livin expression is an independent factor in rectal cancer patients with or without preoperative radiotherapy
Division of Oncology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Country Council of Östergötland, University of Linköping, Linköping, Sweden; Department of Thoracic Oncology, Cancer Center, and the State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.
Örebro University, School of Medicine, Örebro University, Sweden.
Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.
Division of Oncology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Country Council of Östergötland, University of Linköping, Linköping, Sweden.
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2013 (English)In: Radiation Oncology, ISSN 1748-717X, E-ISSN 1748-717X, Vol. 8, no 1, article id 281Article in journal (Refereed) Published
Abstract [en]

Background: This study was aimed to investigate the expression significance of Livin in relation to radiotherapy (RT), clinicopathological and biological factors of rectal cancer patients.

Methods: This study included 144 primary rectal cancer patients who participated in a Swedish clinical trial of preoperative radiotherapy. Tissue microarray samples from the excised primary rectal cancers, normal mucosa and lymph node metastases were immunostained with Livin antibody. The proliferation of colon cancer cell lines SW620 and RKO was assayed after Livin knock-down.

Results: The expression of Livin was significantly increased from adjacent (P = 0.051) or distant (P = 0.028) normal mucosa to primary tumors. 15.4% (2/13) and 39.7% (52/131) patients with Livin-negative and positive tumors died at 180 months after surgery, and the difference tended to be statistically significant (P = 0.091). In multivariate analyses, the difference achieved statistical significance, independent of TNM stage, local and distant recurrence, grade of differentiation, gender, and age (odds ratio = 5.09, 95% CI: 1.01-25.64, P = 0.048). The in vitro study indicated colon cancer cells with Livin knock-down exhibited decreased proliferation compared with controls after RT.

Conclusions: The expression of Livin was was independently related to survival in rectal cancer patients, suggesting Livin as a useful prognostic factor for rectal cancer patients.

Place, publisher, year, edition, pages
London, United Kingdom: BioMed Central, 2013. Vol. 8, no 1, article id 281
Keywords [en]
Rectal cancer, livin, radiotherapy
National Category
Medical and Health Sciences Cancer and Oncology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:oru:diva-34273DOI: 10.1186/1748-717X-8-281ISI: 000331620900002PubMedID: 24295240Scopus ID: 2-s2.0-84888631845OAI: oai:DiVA.org:oru-34273DiVA, id: diva2:704947
Funder
Swedish Research CouncilSwedish Cancer Society
Note

Funding Agencies:

National Major Project of China

National Natural Science Fund of China

Health Research Council in the South-East of Sweden

Available from: 2014-03-13 Created: 2014-03-13 Last updated: 2017-12-05Bibliographically approved

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Zhang, Hong

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