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Case-control study on perfluorinated alkyl acids (PFAAs) and the risk of prostate cancer
School of Science and Technology, Örebro University, Örebro, Sweden. (MTM Research Centre)
Örebro University, School of Science and Technology. (MTM Research Centre)
Örebro University, School of Science and Technology. (MTM Research Centre)ORCID iD: 0000-0001-6217-8857
School of Science and Technology, Örebro University, Örebro, Sweden. (MTM Research Centre)
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2014 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 63, p. 35-39Article in journal (Refereed) Published
Abstract [en]

Perfluorinated alkyl acids (PFAAs) are emerging environmental contaminants. Possible health effects for humans include increased risk for cancer but the knowledge is limited. In this study serum concentrations of certain perfluorinated sulfonates (PFHxS and PFOS) and carboxylates (PFOA, PFNA, PFDA, PFUnDA) were analyzed among 201 cases with prostate cancer and 186 population based control subjects. All blood samples were collected during 2007-2011 and no case had been treated with radio- or chemotherapy before enrolment in the study. The blood concentrations did not differ statistically significant between cases and controls except for PFDA with higher concentration among the cases (p = 0.03). Analyses based on Gleason score and prostate specific antigen (PSA) level did not change the results. Heredity was a risk factor for prostate cancer yielding odds ratio (OR) = 1.8, 95% confidence interval (CI) = 1.01-3.1. The analyzed PFAAs yielded statistically significant higher ORs in cases with a first degree relative reporting prostate cancer, e.g., PFOA gave OR = 2.6, 95% CI = 1.2-6.0 and PFOS gave OR = 2.7,95% CI = 1.04-6.8. The results showed a higher risk for prostate cancer in cases with heredity as a risk factor. In further studies interaction between gene and environment should be considered. (C) 2013 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 63, p. 35-39
Keywords [en]
PFOS, PFOA, Heredity, Risk factors, Prostate cancer
National Category
Environmental Sciences
Research subject
Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-34263DOI: 10.1016/j.envint.2013.10.005ISI: 000330909900005PubMedID: 24246240Scopus ID: 2-s2.0-84887579728OAI: oai:DiVA.org:oru-34263DiVA, id: diva2:705086
Funder
Swedish Cancer Society
Note

Funding Agencies:

Cancerhjälpen

Odd Fellow Örebro

Örebro University Hospital Cancer Fund 

Available from: 2014-03-14 Created: 2014-03-13 Last updated: 2018-06-05Bibliographically approved

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Kärrman, Annavan Bavel, BertHardell, Lennart

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