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Circulating levels of p,p '-DDE are related to prevalent hypertension in the elderly
Dept Med Sci Occupat & Environm Med, Uppsala Univ, Uppsala, Sweden.
Dept Med Sci Occupat & Environm Med, Uppsala Univ, Uppsala, Sweden.
Örebro University, School of Science and Technology.ORCID iD: 0000-0001-5752-4196
Örebro University, School of Science and Technology.ORCID iD: 0000-0001-6217-8857
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2014 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 129, p. 27-31Article in journal (Refereed) Published
Abstract [en]

Background: Polychlorinated biphenyls (PCBs) and dioxin given to experimental animals increase the blood pressure. We therefore investigated if circulating levels of persistent organic pollutants (POPs) were related to hypertension in a population-based sample of men and women.

Methods: One thousand and sixteen subjects aged 70 years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Twenty-three POPs were analyzed using high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). Hypertension was defined as a systolic blood pressure >= 140 mmHg or a diastolic blood pressure >= 90 mmHg, and/or use of antihypertensive medication.

Results: Seven hundred and thirty-two subjects (72%) showed hypertension. When the POPs were treated as continuous variables and adjusted for gender only, two PCBs with a low number of chlorine atoms (PCB 105 and 118) were related to prevalent hypertension. Also the OC pesticide p,p'-DDE was related to hypertension. The strongest of these associations was seen for p,p'-DDE (OR 135 for a 1 SD change, 95% CI 1.17-1.56, p < 0.0001). Following further adjustment also for BMI, smoking status, education level and exercise habits, only p,p'-DDE was still significantly related to hypertension (OR 1.23 for a 1 SD change, 95% CI 1.06-1.43, p=0.006).

Conclusion: In this cross-sectional analysis of an elderly population, high levels of circulating levels of p,p'-DDE were associated with prevalent hypertension, further strengthening the experimental findings that POPs might influence blood pressure. (C) 2013 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
San Diego: Academic Press, 2014. Vol. 129, p. 27-31
Keywords [en]
Hypertension, Elderly, Persistent organic pollutants, Polychlorinated biphenyls, DDE
National Category
Chemical Sciences
Research subject
Environmental Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-34635DOI: 10.1016/j.envres.2013.12.003ISI: 000331921100004OAI: oai:DiVA.org:oru-34635DiVA, id: diva2:711065
Funder
Swedish Research Council
Note

Funding Agency:

Swedish Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS)

Available from: 2014-04-09 Created: 2014-04-09 Last updated: 2018-06-05Bibliographically approved

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Salihovic, Samiravan Bavel, Bert

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