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Folic acid supplementation and IVF pregnancy outcome in women with unexplained infertility
Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden.
Dept Womens & Childrens Hlth, Uppsala Univ, Uppsala, Sweden.
Örebro University, School of Hospitality, Culinary Arts & Meal Science. Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.ORCID iD: 0000-0002-7165-279X
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Medical Biosciences, Umeå University, Umeå, Sweden.
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2014 (English)In: Reproductive Biomedicine Online, ISSN 1472-6483, E-ISSN 1472-6491, Vol. 28, no 6, p. 766-772Article in journal (Refereed) Published
Abstract [en]

Folic acid supplements are commonly used by infertile women and lead to a positive folate status. However, the effect of folic acid supplements on pregnancy outcome in women with unexplained infertility has not been well investigated. This study evaluated folic acid supplement use and folate status in women with unexplained infertility in relation to pregnancy outcome. In addition, use of folic acid supplements and folate status were compared between women with unexplained infertility and fertile, nonpregnant control women. Women with unexplained infertility used significantly more folic acid supplements and had higher median total folic acid intake from supplements compared with fertile control women (both P < 0.001). Women with unexplained infertility also had significantly higher median plasma folate and lower median plasma homocysteine concentrations than fertile women (both P < 0.001), but folic acid supplementation or folate status were not related to pregnancy outcome in women with unexplained infertility. In conclusion, folic acid supplementation or good folate status did not have a positive effect on pregnancy outcome following infertility treatment in women with unexplained infertility.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 28, no 6, p. 766-772
Keywords [en]
dietary supplement, folate, homocysteine, infertility, pregnancy
National Category
Social Sciences
Research subject
Culinary Arts and Meal Science
Identifiers
URN: urn:nbn:se:oru:diva-34682DOI: 10.1016/j.rbmo.2014.01.017ISI: 000338862000014PubMedID: 24745837Scopus ID: 2-s2.0-84901938999OAI: oai:DiVA.org:oru-34682DiVA, id: diva2:711296
Funder
EU, FP7, Seventh Framework Programme, EU41564EU, FP7, Seventh Framework Programme, SARM, EU324509
Note

Funding Agencies:

Family Planning Foundation

Födelsefonden, Uppsala, Sweden

Regional Research Foundation, Örebro, Sweden

Pampers Scholarship, Sweden

Praktikertjänst, Stockholm, Sweden

Marie Curie postdoctoral fellowship 329812

Available from: 2014-04-09 Created: 2014-04-09 Last updated: 2018-06-05Bibliographically approved

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Yngve, AgnetaNilsson, Torbjörn K.

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Yngve, AgnetaNilsson, Torbjörn K.
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School of Hospitality, Culinary Arts & Meal ScienceSchool of Health and Medical Sciences, Örebro University, Sweden
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