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Ischaemic heart disease in first-degree relatives to coeliac patients
Örebro University, School of Medicine, Örebro University, Sweden. Primary Care Res Unit, Värmlands Nysäter, Värmland County Council, Karlstad, Sweden.ORCID iD: 0000-0001-9137-2800
Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Örebro University Hospital. Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0003-1024-5602
2014 (English)In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 44, no 4, p. 359-364Article in journal (Refereed) Published
Abstract [en]

Objective: Coeliac disease (CD) has been linked to an increased risk of ischaemic heart disease (IHD). We examined the risk of IHD in first-degree relatives and spouses to coeliac patients to ascertain the genetic contribution to IHD excess risk.

Study design and setting: Coeliac disease was defined as having a biopsy-verified villous atrophy (Marsh grade 3) in 1969-2008 (n=29096). Coeliac patients were matched to 144522 controls. Through Swedish registers, we identified all first-degree relatives and spouses to coeliac patients and their controls, in total 87622 unique coeliac relatives and 432655 unique control relatives. Our main outcome measure was IHD defined according to relevant international classification of disease codes in the Swedish Inpatient Registry or in the Cause of Death Registry. Hazard ratios (HR) and confidence intervals (CI) were estimated through Cox regression adjusted for sex, age-group and calendar year at study entry of the relative.

Result: During a median follow-up of 108 years, 2880 coeliac relatives and 13817 control relatives experienced IHD. First-degree relatives of coeliac patients were at increased risk of IHD (HR=105; 95% CI=100-109, P-value=004), while spouses were at no increased risk (HR=099; 95% CI=087-112). The excess risk of IHD in coeliac first-degree relatives aged 40-59years was 70/100000 person-years.

Conclusion: First-degree relatives to coeliac patients seem to be at an increased risk of IHD but the excess risk is so small that it has little clinical relevance.

Place, publisher, year, edition, pages
Hoboken: Wiley-Blackwell, 2014. Vol. 44, no 4, p. 359-364
Keywords [en]
Celiac, coeliac, cohort, ischaemic heart disease, risk factors, shared genetics
National Category
General Practice
Identifiers
URN: urn:nbn:se:oru:diva-34845DOI: 10.1111/eci.12242ISI: 000332586300003PubMedID: 24476531Scopus ID: 2-s2.0-84895930474OAI: oai:DiVA.org:oru-34845DiVA, id: diva2:714481
Funder
Swedish Research CouncilSwedish Society for Medical Research (SSMF)
Note

Funding Agencies:

Värmland County

Örebro Society of Medicine

Swedish Celiac Society

Available from: 2014-04-28 Created: 2014-04-25 Last updated: 2018-08-28Bibliographically approved

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Emilsson, LouiseLudvigsson, Jonas F.

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