Prevention field has achieved major advances in developing, implementing, and testing the efficacy of preventive interventions in controlled settings. Nevertheless, there is still a gap in translating the success of programs in efficacy trials into real-life settings. Dissemination of evidence-based programs is a major challenge. The authors argue that promoting adoption of evidence-based programs requires further improvements in three areas, and collaboration between researchers and practitioners. First, there is a need to develop a holistic assessment system encompassing both risk/need and readiness assessments. Second, there is need for new methods for improving implementation quality. Third, prevention research needs to focus more on identifying the mechanisms that explain how programs work and the core elements of the program. Both researchers and practitioners have roles and opportunities to collaborate to achieve developments in these areas.