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Antibiotic exposure in pregnancy and risk of coeliac disease in offspring: a cohort study
Dept Med Epidemiol & Biostat, Karolinska Inst, Stockholm, Sweden; Astrid Lindgren Childrens Hosp, Karolinska Univ Hosp, Solna, Sweden.
Dept Clin & Expt Med, Div Pediat, Linköping Univ, Linköping, Sweden; Östergötland Cty Council, Linköping, Sweden.
Microbial Ecol & Nutr Res Grp, Instituto De Agroquímica Y Tecnología De Alimentos (IATA) CSIC, Valencia, Spain.
Örebro University Hospital. Dept. Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0003-1024-5602
2014 (English)In: BMC Gastroenterology, ISSN 1471-230X, E-ISSN 1471-230X, Vol. 14, article id 75Article in journal (Refereed) Published
Abstract [en]

Background: The infant microbiota may play a pathogenic role in coeliac disease (CD). Antibiotic treatment in pregnancy is common and could significantly impact the infant microbiota. In this study, we aimed to investigate the association between antibiotic exposure during pregnancy and CD in offspring.

Methods: Prospective questionnaire data on antibiotic exposure in pregnancy were available in 8729 children participating in the All Babies in Southeast Sweden (ABIS) cohort study, and of these 46 developed CD until December 2006. Cox regression estimated hazard ratios (HRs) for CD in the offspring among mothers exposed to antibiotics during pregnancy, with adjustment for parent-reported diary data on breastfeeding, age at gluten introduction and number of infections in the child's first year of life.

Results: Of the 1836 children exposed to antibiotics during pregnancy, 12 (0.7%) children developed CD as compared with 34/6893 (0.5%) unexposed children (HR = 1.33; 95% Cl = 0.69-2.56). Risk estimates remained unchanged after adjustment for breastfeeding, age at gluten introduction and infection load in the child's first year of life (HR = 1.28; 95% Cl = 0.66-2.48).

Conclusions: We found no statistically significant association between antibiotic exposure during pregnancy and CD in offspring. This lack of association may either be true or the result of limited statistical power.

Place, publisher, year, edition, pages
London: BioMed Central, 2014. Vol. 14, article id 75
Keywords [en]
Antibiotics, Celiac disease, Microbiota, Pregnancy
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-35209DOI: 10.1186/1471-230X-14-75ISI: 000335061900001Scopus ID: 2-s2.0-84899658039OAI: oai:DiVA.org:oru-35209DiVA, id: diva2:720995
Funder
Swedish Research Council
Note

Funding Agencies:

KM: The Swedish Society of Medicine

Karolinska Institutet

JL: Swedish Child Diabetes Foundation (Barndiabetesfonden)

Research Council for Southeast Sweden

ALF (Swedish Government)

Canadian Research Council

Östgota Brandstodsbolag

Östergötland County Council

EU Research Grants

YS

Consolider Fun-C-Food

Spanish Ministry of Economy and Competitiveness

JFL: The Swedish Society of Medicine

Örebro Society of Medicine, the Karolinska Institutet

Swedish Celiac Society

Available from: 2014-06-03 Created: 2014-06-02 Last updated: 2018-06-07Bibliographically approved

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Ludvigsson, Jonas F.

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