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An oxygenated metabolite of benzo[a]pyrene increases hepatic beta-oxidation of fatty acids in chick embryos
Örebro University, School of Science and Technology. Structor Miljöteknik AB, Örebro, Sweden. (MTM)
Örebro University, School of Science and Technology. (MTM)
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.ORCID iD: 0000-0001-8102-1804
Institute for Environmental Research, Department of Ecosystem Analysis, RWTH Aachen University, Aachen, Germany.
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2014 (English)In: Environmental science and pollution research international, ISSN 0944-1344, E-ISSN 1614-7499, Vol. 21, no 9, p. 6243-6251Article in journal (Refereed) Published
Abstract [en]

Polycyclic aromatic hydrocarbons (PAHs) are well-known carcinogens to humans and ecotoxicological effects have been shown in several studies. However, PAHs can also be oxidized into more water soluble-oxygenated metabolites (Oxy-PAHs). The first purpose of the present project was to (1) assess the effects of a mixture containing three parent PAHs: anthracene, benz[a]anthracene, and benzo[a]pyrene versus a mixture of their oxygenated metabolites, namely: anthracene-9,10-dione, benz[a]anthracene-7,12-dione, and 9,10-dihydrobenzo[a]pyrene-7-(8H)-one on the hepatic fatty acid beta-oxidation in chicken embryos (Gallus gallus domesticus) exposed in ovo. The second and also main purpose of the project was to (2) assess the effects of the parent PAHs versus their oxy-PAHs analogues when injected individually, followed by (3) additional testing of the individual oxy-PAHs. The hepatic beta-oxidation was measured using a tritium release assay with [9,10-H-3]-palmitic acid (16:0) as substrate. The result from the first part (1) showed reduced hepatic beta-oxidation after exposure in ovo to a mixture of three PAHs, however, increased after exposure to the mixture of three oxy-PAHs compared to control. The result from the second part (2) and also the follow-up experiment (3) showed that 9,10-dihydrobenzo[a]pyrene-7-(8H)-one was the causative oxy-PAH. The implication of this finding on the risk assessment of PAH metabolite exposure in avian wildlife remains to be determined. To the best of our knowledge, no similar studies have been reported.

Place, publisher, year, edition, pages
Heidelberg: Springer Berlin/Heidelberg, 2014. Vol. 21, no 9, p. 6243-6251
Keywords [en]
Polycyclic aromatic hydrocarbons, Oxygenated derivatives, Chick embryo, beta-oxidation
National Category
Biological Sciences Environmental Biotechnology
Research subject
Biology; Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-35205DOI: 10.1007/s11356-013-2471-6ISI: 000334684700049PubMedID: 24385188OAI: oai:DiVA.org:oru-35205DiVA, id: diva2:721119
Note

Funding Agency:

Swedish Knowledge Foundation (Stiftelsen for Kunskaps- och Kompetensutveckling)

Available from: 2014-06-03 Created: 2014-06-02 Last updated: 2017-12-05Bibliographically approved

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Westman, OlaLarsson, MariaVenizelos, NikolaosEngwall, Magnus

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