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Alteration of the intestinal microbiota as a cause of and a potential therapeutic option in irritable bowel syndrome
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. (NGBI)ORCID iD: 0000-0003-0466-1861
Örebro University, School of Medicine, Örebro University, Sweden. Örebro University Hospital. (NGBI)ORCID iD: 0000-0002-0362-0008
2014 (English)In: Beneficial Microbes, ISSN 1876-2883, E-ISSN 1876-2891, Vol. 5, no 3, p. 247-261Article, review/survey (Refereed) Published
Abstract [en]

The intestinal microbiota forms a complex ecosystem that is in close contact with its host and has an important impact on health. An increasing number of disorders are associated with disturbances in this ecosystem. Also patients suffering from irritable bowel syndrome (IBS) show an altered composition of their gut microbiota. IBS is a multifactorial chronic disorder characterised by various abdominal complaints and a worldwide prevalence of 10-20%. Even though its aetiology and pathophysiology are complex and not well understood, it is widely accepted that aberrations along the microbe-gut-brain axis are involved. In this review, it will be discussed how exogenous factors, e.g. antibiotics, can cause disbalance in the intestinal microbiota and thereby contribute to the development of IBS. In addition, several new IBS treatment options that aim at re-establishing a healthy, beneficial ecosystem will be described. These include antibiotics, probiotics, prebiotics and faecal transplantation.

Place, publisher, year, edition, pages
Wageningen Academic Publishers, 2014. Vol. 5, no 3, p. 247-261
Keywords [en]
gut microbiota, antibiotics, probiotics, prebiotics, faecal transplantation
National Category
Nutrition and Dietetics Microbiology in the medical area
Research subject
Biomedicine
Identifiers
URN: urn:nbn:se:oru:diva-35263DOI: 10.3920/BM2013.0033ISI: 000347675000003PubMedID: 24583610Scopus ID: 2-s2.0-84904070878OAI: oai:DiVA.org:oru-35263DiVA, id: diva2:722212
Available from: 2014-06-05 Created: 2014-06-05 Last updated: 2018-01-11Bibliographically approved

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König, JuliaBrummer, Robert-Jan

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School of Health and Medical Sciences, Örebro University, SwedenSchool of Medicine, Örebro University, SwedenÖrebro University Hospital
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Beneficial Microbes
Nutrition and DieteticsMicrobiology in the medical area

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