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Association Between IgA Deficiency & Other Autoimmune Conditions: A Population-Based Matched Cohort Study
Örebro University Hospital. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden .ORCID iD: 0000-0003-1024-5602
Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
2014 (English)In: Journal of Clinical Immunology, ISSN 0271-9142, E-ISSN 1573-2592, Vol. 34, no 4, p. 444-451Article in journal (Refereed) Published
Abstract [en]

Purpose: To examine autoimmune disorders in patients with IgA deficiency compared with the general population.

Methods: Nationwide prospective population-based cohort study. Through six university hospitals in Sweden we identified 2100 individuals with IgA deficiency (IgA levels < .07 g/L) diagnosed between 1980 and 2011. Each patient with IgA deficiency was matched on age, sex, place of residence, and year of diagnosis with up to 10 general population controls (n = 18,653). Data on nine autoimmune disorders were retrieved from the Swedish National Patient Register (including inpatient and non-primary outpatient care). Autoimmune disorders were defined as having at least two visits listing the relevant international classification of disease (ICD) code as main diagnosis. Prevalences and prevalence ratios (PRs) were calculated.

Results: Individuals with IgA deficiency more often had celiac disease (6.7 % vs. 0.19 % in controls) and type 1 diabetes (5.9 % vs. 0.57 %) corresponding to a 35-fold higher PR for celiac disease and 10-fold higher for type 1 diabetes. Also for the other autoimmune diseases did we see statistically significantly elevated prevalences and PRs (juvenile idiopathic arthritis (0.76 % vs. 0.09 % in controls, PR = 8.9), systemic lupus erythematosus (0.57 % vs. 0.06 %; PR = 8.9), inflammatory bowel disease (3.9 % vs. 0.81 %; PR = 5.0; specifically Crohn's disease (2.4 % vs. 0.42 %; PR = 5.7) and ulcerative colitis (1.7 % vs. 0.46 %; PR = 3.9)), hypothyreosis (0.76 % vs. 0.16 %; PR = 4.6), rheumatoid arthritis (2.2 % vs. 0.50 %; PR = 4.5), and hyperthyreosis (1.7 % vs. 0.43 %; PR = 3.9), but not with myasthenia gravis (0.05 % vs. 0.02 %; PR = 3.0).

Conclusions: Individuals with IgA deficiency have a higher prevalence of several other autoimmune disorders.

Place, publisher, year, edition, pages
New York: Springer, 2014. Vol. 34, no 4, p. 444-451
Keywords [en]
Autoimmune, IgA deficiency, immunoglobulin
National Category
Immunology in the medical area
Research subject
Immunology
Identifiers
URN: urn:nbn:se:oru:diva-35353DOI: 10.1007/s10875-014-0009-4ISI: 000336048700006PubMedID: 24584841Scopus ID: 2-s2.0-84901400545OAI: oai:DiVA.org:oru-35353DiVA, id: diva2:724667
Funder
Swedish Research Council
Note

Funding Agency:

Swedish Society of Medicine

Available from: 2014-06-13 Created: 2014-06-13 Last updated: 2018-01-11Bibliographically approved

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Ludvigsson, Jonas F.

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