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Aberrant mucosal lymphocyte number and subsets in the colon of post-infectious irritable bowel syndrome patients
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.ORCID iD: 0000-0003-4713-1772
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University, School of Medicine, Örebro University, Sweden.ORCID iD: 0000-0003-3383-9219
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
Örebro University, School of Medicine, Örebro University, Sweden.ORCID iD: 0000-0001-5460-8888
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2014 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 49, no 9, p. 1068-1075Article in journal (Refereed) Published
Abstract [en]

Background: Irritable bowel syndrome (IBS) is characterized by chronic abdominal symptoms such as pain, discomfort, and altered bowel habits. A subset of IBS patients, denoted as post-infectious IBS (PI-IBS) patients, develop symptoms after an enteric infection. Distinct abnormalities in the gut mucosa, including mucosal inflammation, have been proposed to contribute to or be the cause of PI-IBS. This study investigated lymphocyte subsets in PI-IBS patients compared to healthy controls.

Materials and methods: Ten PI-IBS patients and nine healthy controls participated. All PI-IBS patients met the Rome III diagnostic criteria for IBS and reported sustained symptoms at least 1 year after an episode of acute gastroenteritis. Intraepithelial lymphocytes and lamina propria lymphocytes (LPLs), isolated from mucosal tissue samples, were stained and analyzed for a comprehensive set of cell markers using flow cytometry.

Results: The number of LPLs in PI-IBS was significantly increased compared to those in healthy controls (p < 0.05). PI-IBS patients showed significantly increased proportions of CD45RO(+) CD4(+) activated/memory T cells (p < 0.05) and double-positive CD4(+) CD8(+) cells (p < 0.05), respectively, in the lamina propria. The number of CD19(+) LPLs was decreased in PI-IBS patients compared to healthy controls (p < 0.001).

Conclusion: This study presents new evidence that PI-IBS is associated with a sustained aberrant mucosal immune response and support future studies of anti-inflammatory or immune-modulating treatments in these patients.

Place, publisher, year, edition, pages
Informa Healthcare, 2014. Vol. 49, no 9, p. 1068-1075
Keywords [en]
cell biology, gastrointestinal, infections, health economy, immunology
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-35383DOI: 10.3109/00365521.2014.926982ISI: 000340829900006PubMedID: 24919810Scopus ID: 2-s2.0-84906318425OAI: oai:DiVA.org:oru-35383DiVA, id: diva2:725759
Note

Funding Agency:

Medical Faculty, Örebro University

Available from: 2014-06-17 Created: 2014-06-17 Last updated: 2017-12-05Bibliographically approved
In thesis
1. Microbe-host interactions in post-infectious irritable bowel syndrome
Open this publication in new window or tab >>Microbe-host interactions in post-infectious irritable bowel syndrome
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university, 2015. p. 97
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 114
Keywords
IBS, PI-IBS, Intestinal, Mucosa, Lymphocyte, Microbiota, Bacteria, Cytokine, Addaptive immune response, IL-13
National Category
Gastroenterology and Hepatology
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-41109 (URN)978-91-7529-057-7 (ISBN)
Public defence
2015-02-27, Prismahuset, Hörsal 2, Örebro universitet, Fakultetsgatan 1, Örebro, 09:00 (English)
Opponent
Supervisors
Available from: 2015-01-13 Created: 2015-01-13 Last updated: 2017-10-17Bibliographically approved

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Sundin, JohannaRangel, IgnacioKumawat, Ashok KHultgren-Hörnquist, ElisabethBrummer, Robert J

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Sundin, JohannaRangel, IgnacioKumawat, Ashok KHultgren-Hörnquist, ElisabethBrummer, Robert J
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School of Health and Medical Sciences, Örebro University, SwedenSchool of Medicine, Örebro University, SwedenÖrebro University Hospital
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Scandinavian Journal of Gastroenterology
Gastroenterology and Hepatology

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