oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Role of Selective Estrogen Receptors B Agonist on Chronic Lymphocytic Leukemia Growth in Vitro
Örebro University, School of Science and Technology, Örebro University, Sweden.
2014 (English)Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
Abstract [en]

The estrogen receptor alpha (ERa) and estrogen receptor beta (ER~) have been demonstrated to be important for immune system regulation and studies have suggested an antiproliferative effect of ER~ in lymphoid malignancies. We have studied the expression of ERa and ER~ in peripheral blood mononuclear cells from patients with chronic lymphocytic leukemia (CLL). Expression of ERa was low, while ER~ was highly expressed in CLL cells. In order to investigate the possible inhibitory effect of ligand-activated ER~ , we treated CLL cells and Mecl cell lines with the selective ER~ agonist diarypropionitrile (DPN) in culture. Treating Mecl cell lines with DPN showed an antiproliferative effect of ER~ agonist by significantly inhibit the growth of Mec 1 cell lines. This suggests that ER~ agonist may be useful in the treatment of CLL.

Place, publisher, year, edition, pages
2014. , 25 p.
Keyword [en]
Chronic lymphocytic leukemia, diarypropionitrile, estrogen receptor B
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:oru:diva-35412OAI: oai:DiVA.org:oru-35412DiVA: diva2:726414
Subject / course
Biology
Supervisors
Examiners
Available from: 2014-06-18 Created: 2014-06-18 Last updated: 2014-06-18Bibliographically approved

Open Access in DiVA

fulltext(8793 kB)589 downloads
File information
File name FULLTEXT01.pdfFile size 8793 kBChecksum SHA-512
84d737b1ae78d25bcac89158cdccc8cd144c44d6fdfdb1be11f08318173e652c79bf90124556e46f1aa166c17b9857761efb8466763392be212fbb1c44425f95
Type fulltextMimetype application/pdf

By organisation
School of Science and Technology, Örebro University, Sweden
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 589 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 147 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf