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Sedation and analgesia for neonates in NICUs across the United Kingdom: The Europain survey.
Trousseau Hospital, Paris, France; Inserm U953, Paris, France; UPMC, Paris, France.
Trousseau Hospital, Paris, France; Inserm U953, Paris, France; UPMC, Paris, France.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. (Stress och smärta i nyföddhetsperioden)ORCID iD: 0000-0002-5996-2584
Karolinska University Hospital, Stockholm.
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2014 (English)In: Archives of Disease in Childhood: Fetal and Neonatal Edition, ISSN 1359-2998, E-ISSN 1468-2052, Vol. 99 (Suppl 1), A62-A62 p., PC.77Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Background: Pain and stress induced by mechanical ventilation, invasive procedures, or painful diseases supports the use of sedation/analgesia (S/A) in newborns admitted to Neonatal Units (NNUs). To date, these practices have not been studied on a large scale.

Objective: To determine current clinical practices regarding the use of S/A drugs in NNUs across the United Kingdom (UK).

Design/Methods: A European epidemiological observational study on clinical practices regarding bedside use of S/A collected data for all neonates in participating NNUs until the infant left the unit (discharge, death, transfer) or for up to 28 days. Data collection occurred via an online database for 1 month at each NNU. Neonates up to 44 weeks gestation were included.

Results: From February 2013 to May 2013, 66 UK NNUs collected data on 2691 eligible neonates. Of these, 713 received tracheal ventilation and 1978 had spontaneous breathing or non-invasive ventilation. The median (IQR) gestational age of ventilated neonates [32.1 (27.9-38.6)] was lower than for non-ventilated neonates [37.0 (34.1-39.7), p < 0.001]. Overall, more ventilated neonates [83.0% (n = 592)] received S/A drugs than non-ventilated neonates [7.4% (n = 147); p < 0.001]. The table shows S/A drugs used in ventilated neonates. fetalneonatal;99/Suppl_1/A62-b/T1T1T1 Abstract PC.77 Table   Ventilated and S/A, n = 592 Non-ventilated, and S/A n = 147 Fentanyl 105 (17.7%) 4 (2;7%) Midazolam 55 (9.3%) 3 (2.0%) Paracetamol 17 (2.9%) 92 (62.6%) Morphine 592 (91.6%) 44 (29.9%) Sufentanil 2 (0.3%) 0 Neuroblocker 352 (59.4%) 0 CONCLUSIONS: Most ventilated but few non-ventilated neonates receive S/A therapy in UK NNUs. Wide variations in rates of S/A use and drugs used exist among centres.

Place, publisher, year, edition, pages
London, United Kingdom: BMJ Group , 2014. Vol. 99 (Suppl 1), A62-A62 p., PC.77
Keyword [en]
Pain, Newborn, Neonatal, Pain Assessment
National Category
Pediatrics
Research subject
Caring Sciences w. Medical Focus
Identifiers
URN: urn:nbn:se:oru:diva-35800DOI: 10.1136/archdischild-2014-306576.178OAI: oai:DiVA.org:oru-35800DiVA: diva2:735318
Conference
Perinatal Medicine 2014, Harrogate, UK, 9-11 June, 2014.
Projects
EUROPAINNeoOpioid
Funder
EU, FP7, Seventh Framework Programme, 223767
Available from: 2014-07-25 Created: 2014-07-25 Last updated: 2017-10-17Bibliographically approved

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Eriksson, Mats
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CiteExportLink to record
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