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Proteasome activation delays aging in vitro and in vivo
Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Athens, Greece.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Athens, Greece.
Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Athens, Greece.
Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Athens, Greece.
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2014 (English)In: Free Radical Biology & Medicine, ISSN 0891-5849, E-ISSN 1873-4596, Vol. 71, 303-320 p.Article, review/survey (Refereed) Published
Abstract [en]

Aging is a natural biological process that is characterized by a progressive accumulation of macromolecular damage. In the proteome, aging is accompanied by decreased protein homeostasis and function of the major cellular proteolytic systems, leading to the accumulation of unfolded, misfolded, or aggregated proteins. In particular, the proteasome is responsible for the removal of normal as well as damaged or misfolded proteins. Extensive work during the past several years has clearly demonstrated that proteasome activation by either genetic means or use of compounds significantly retards aging. Importantly, this represents a common feature across evolution, thereby suggesting proteasome activation to be an evolutionarily conserved mechanism of aging and longevity regulation. This review article reports on the means of function of these proteasome activators and how they regulate aging in various species. (C) 2014 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
New York: Elsevier, 2014. Vol. 71, 303-320 p.
Keyword [en]
Ubiquitin-proteasome system, Proteasome activation, Aging, Senescence, Longevity regulation, Free radicals
National Category
Biochemistry and Molecular Biology
Research subject
Molecular Biology; Biochemistry
Identifiers
URN: urn:nbn:se:oru:diva-35834DOI: 10.1016/j.freeradbiomed.2014.03.031ISI: 000336891100027OAI: oai:DiVA.org:oru-35834DiVA: diva2:735688
Note

Funding Agencies:

European Union (European Social Fund)

Greek national funds through the Operational Program "Education and Lifelong Learning" of the National Strategic Reference Framework

SYNERGASIA project

KRIPIS

IKYDA

John S. Latsis Public Benefit Foundation

EU

Available from: 2014-07-30 Created: 2014-07-30 Last updated: 2017-10-17Bibliographically approved

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