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Impairment in Guillain-Barré syndrome during the first 2 years after onset: A prospective study
Karolinska Institutet, Karolinska University Hospital at Huddinge, Stockholm, Sweden.
Karolinska Institutet, Karolinska University Hospital at Huddinge, Stockholm, Sweden.
Karolinska Institutet, Karolinska University Hospital at Huddinge, Stockholm, Sweden; National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain.
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2004 (English)In: Journal of the Neurological Sciences, ISSN 0022-510X, E-ISSN 1878-5883, Vol. 227, no 1, 131-138 p.Article in journal (Refereed) Published
Abstract [en]

Objectives

To provide a comprehensive description of impairment in patients with Guillain–Barré syndrome (GBS) in Sweden during the first 2 years after disease onset.

Methods

In this prospective multi-centre study, 42 patients, mean age 52 years, were evaluated at 2 weeks, 2 months, 6 months, 1 year and 2 years. Evaluations made use of validated, reliable measures of muscle strength, grip strength, finger dexterity, balance, facial-muscle function, respiratory function, gait, motor performance and sensory examination, and included patients' owns assessments of pain, fatigue and paraesthesia.

Results

Mechanical ventilation was required in 21% of patients. At 2 weeks, 1 year and 2 years after GBS onset: 100%, 62% and 55% of patients had submaximal overall muscle strength; 98%, 38% and 31% subnormal grip strength; and 38%, 14% and 12% affected facial-muscle function. At the same time points, 62%, 10% and 7% of patients were unable to walk 10 m independently; and affected sensation was detected in 93%, 55% and 52%.

Conclusions

Recovery occurred mainly during the first year after onset. At 2 years, motor impairment and sensory impairment were each still detectable in more than 50% of patients. We conclude that residual impairment is significant, somatically widespread and, likely, persistent.

Place, publisher, year, edition, pages
2004. Vol. 227, no 1, 131-138 p.
National Category
Health Sciences Neurology
Research subject
Health and Medical Care Research
Identifiers
URN: urn:nbn:se:oru:diva-35849DOI: 10.1016/j.jns.2004.09.021ISI: 000225529900019PubMedID: 15546603OAI: oai:DiVA.org:oru-35849DiVA: diva2:735911
Available from: 2014-08-04 Created: 2014-08-04 Last updated: 2017-10-17Bibliographically approved

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