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Low gut microbiota diversity in early infancy precedes asthma at school age
Linköping Univ, Dept Clin & Expt Med, Div Pediat, Linköping, Sweden.
Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
KTH Royal Inst Technol, Sch Biotechnol, Div Gene Technol, Sci Life Lab, Stockholm, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
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2014 (English)In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 44, no 6, 842-850 p.Article in journal (Refereed) Published
Abstract [en]

Background Low total diversity of the gut microbiota during the first year of life is associated with allergic diseases in infancy, but little is known how early microbial diversity is related to allergic disease later in school age. Objective To assess microbial diversity and characterize the dominant bacteria in stool during the first year of life in relation to the prevalence of different allergic diseases in school age, such as asthma, allergic rhinoconjunctivitis (ARC) and eczema. Methods The microbial diversity and composition was analysed with barcoded 16S rDNA 454 pyrosequencing in stool samples at 1week, 1month and 12months of age in 47 infants which were subsequently assessed for allergic disease and skin prick test reactivity at 7years of age (ClinicalTrials.gov ID NCT01285830). Results Children developing asthma (n=8) had a lower diversity of the total microbiota than non-asthmatic children at 1week (P=0.04) and 1month (P=0.003) of age, whereas allergic rhinoconjunctivitis (n=13), eczema (n=12) and positive skin prick reactivity (n=14) at 7years of age did not associate with the gut microbiota diversity. Neither was asthma associated with the microbiota composition later in infancy (at 12months). Children having IgE-associated eczema in infancy and subsequently developing asthma had lower microbial diversity than those that did not. There were no significant differences, however, in relative abundance of bacterial phyla and genera between children with or without allergic disease. Conclusion and Clinical Relevance Low total diversity of the gut microbiota during the first month of life was associated with asthma but not ARC in children at 7years of age. Measures affecting microbial colonization of the infant during the first month of life may impact asthma development in childhood.

Place, publisher, year, edition, pages
2014. Vol. 44, no 6, 842-850 p.
Keyword [en]
asthma, allergic rhinoconjunctivitis, birth, children, diversity, hygiene hypothesis, microbiota, molecular microbiology
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-35822DOI: 10.1111/cea.12253ISI: 000337529100006OAI: oai:DiVA.org:oru-35822DiVA: diva2:741017
Funder
Swedish Heart Lung FoundationSwedish Research Council
Note

Funding Agency:

BioGaia AB, Stockholm, Sweden

Ekhaga Foundation

Research Council for the South-East Sweden

Olle Engkvist Foundation

Swedish Asthma and Allergy Association

University Hospital of Linkoping

Soderberg Foundation

Vardal Foundation for Health Care Science and Allergy Research, Sweden

Available from: 2014-08-27 Created: 2014-07-30 Last updated: 2017-10-17Bibliographically approved

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