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Genetic Variation Across C-Reactive Protein and Risk of Prostate Cancer
Sch Publ Hlth, Dept Epidemiol, Harvard Univ, Boston, USA.
Sch Publ Hlth, Dept Epidemiol, Harvard Univ, Boston, USA; Dept Med, Channing Div Network Med, Brigham & Womens Hosp, Boston, USA; Sch Med, Harvard Univ, Boston, USA .
Sch Publ Hlth, Dept Epidemiol, Harvard Univ, Boston, USA; Dept Med, Channing Div Network Med, Brigham & Womens Hosp, Boston, USA; Sch Med, Harvard Univ, Boston, USA .
Keck Sch Med, Dept Prevent Med, Univ So Calif, Los Angeles, USA.
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2014 (English)In: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 74, no 10, p. 1034-1042Article in journal (Refereed) Published
Abstract [en]

BACKGROUND. Inflammation has been hypothesized to play an important etiological role in the initiation or progression of prostate cancer. Circulating levels of the systemic inflammation marker C-reactive protein (CRP) have been associated with increased risk of prostate cancer. We investigated the role of genetic variation in CRP and prostate cancer, under the hypothesis that variants may alter risk of disease.

METHODS. We undertook a case-control study nested within the prospective Physicians' Health Study among 1,286 men with incident prostate cancer and 1,264 controls. Four single-nucleotide polymorphisms (SNPs) were selected to capture the common genetic variation across CRP (r(2) > 0.8). We used unconditional logistic regression to assess the association between each SNP and risk of prostate cancer. Linear regression models explored associations between each genotype and plasma CRP levels.

RESULTS. None of the CRP SNPs were associated with prostate cancer overall. Individuals with one copy of the minor allele (C) in rs1800947 had an increased risk of high-grade prostate cancer (OR: 1.7; 95% CI: 1.1-2.8), and significantly lower mean CRP levels (P-value < 0.001), however, we found no significant association with lethal disease. Mean CRP levels were significantly elevated in men with one or two copies of the minor allele in rs3093075 and rs1417939, but these were unrelated to prostate cancer risk.

CONCLUSION. Our findings suggest that SNPs in the CRP gene are not associated with risk of overall or lethal prostate cancer. Polymorphisms in CRP rs1800947 may be associated with higher grade disease, but our results require replication in other cohorts.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2014. Vol. 74, no 10, p. 1034-1042
Keywords [en]
CRP SNPs, prostate cancer, inflammation
National Category
Cancer and Oncology Endocrinology and Diabetes Urology and Nephrology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:oru:diva-35809DOI: 10.1002/pros.22820ISI: 000338039500004PubMedID: 24844401Scopus ID: 2-s2.0-84901697261OAI: oai:DiVA.org:oru-35809DiVA, id: diva2:741465
Funder
NIH (National Institute of Health), R25 CA098566 T32 CA09001-35
Note

Funding Agencies:

Prostate Cancer Foundation

National Cancer Institute CA42182  CA34944  CA40360  CA141298  CA097193

National Heart, Lung, and Blood Institute (Bethesda, MD) HL26490  HL34595

Available from: 2014-08-28 Created: 2014-07-30 Last updated: 2018-08-28Bibliographically approved

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Fall, Katja

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