oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Are increased levels of systemic oxidative stress and inflammation associated with age-related cataract?
Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, Stockholm, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden.
Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, Stockholm, Sweden.
Uppsala Univ, Dept Surg Sci, Sect Orthopaed, Uppsala, Sweden.
Show others and affiliations
2014 (English)In: Antioxidants and Redox Signaling, ISSN 1523-0864, E-ISSN 1557-7716, Vol. 21, no 5, 700-704 p.Article in journal (Refereed) Published
Abstract [en]

Oxidative stress and inflammation may be involved in the etiology of age-related cataract. This study is the first to investigate the association between urinary levels of 8-iso-prostaglandin F-2 alpha (PGF(2 alpha); as a biomarker for systemic oxidative stress in vivo) and 15-keto-dihydro-PGF(2 alpha) (as a biomarker for systemic inflammation in vivo) and risk of age-related cataract. We observed in a nested case-control study, including 258 women with incident cataract diagnosis and/or cataract extraction and 258 women without cataract, matched on age and date of urine sample collection that, women with higher levels of urinary 8-iso-PGF(2 alpha) as compared with lower levels had an increased risk of age-related cataract. There was no difference in 15-keto-dihydro-PGF(2 alpha) levels between cases and controls. Our observations lead to the hypothesis that higher systemic oxidative stress increases the risk of developing age-related cataract.

Place, publisher, year, edition, pages
Mary Ann Liebert, 2014. Vol. 21, no 5, 700-704 p.
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Endocrinology and Diabetes
Research subject
Molecular Biology; Biochemistry
Identifiers
URN: urn:nbn:se:oru:diva-36153DOI: 10.1089/ars.2014.5853ISI: 000339660000003PubMedID: 24527727Scopus ID: 2-s2.0-84904440496OAI: oai:DiVA.org:oru-36153DiVA: diva2:743045
Note

Funding Agencies:

Swedish Research Council for Health, Working Life and Welfare, Stockholm, Sweden

Swedish Research Council/Committee for Infrastructure, Stockholm, Sweden

Karolinska Institutet's Foundation Grants for Eye Research

Available from: 2014-09-03 Created: 2014-08-28 Last updated: 2017-10-18Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Lindblad, Birgitta Ejdervik
By organisation
School of Health and Medical Sciences, Örebro University, SwedenÖrebro University Hospital
In the same journal
Antioxidants and Redox Signaling
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 45 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf