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Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease: An ECCO-EpiCom study
Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark .
Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark .
Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark .
Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia .
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2014 (English)In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 8, no 9, 1030-1042 p.Article in journal (Refereed) Published
Abstract [en]

Background & Aims: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe.

Methods: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1 million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up.

Results: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population.

Conclusion: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest.

Place, publisher, year, edition, pages
Oxford, United Kingdom: Oxford University Press, 2014. Vol. 8, no 9, 1030-1042 p.
Keyword [en]
Quality of life, epidemiology, inception cohort, disease course
National Category
Gastroenterology and Hepatology
Research subject
Internal Medicine
Identifiers
URN: urn:nbn:se:oru:diva-37062DOI: 10.1016/j.crohns.2014.01.028ISI: 000342264900014PubMedID: 24560877Scopus ID: 2-s2.0-84906791641OAI: oai:DiVA.org:oru-37062DiVA: diva2:748412
Note

Munkholm, P. On behalf of the EpiCom-group

Valpiani D., Boni M. C.  On behalf of the EpiCom Northern Italy centre based in Crema and oCremona, Firenze, Forlì, Padova and Reggio Emilia, Italy 

Funding Agencies:

Danish Colitis Crohn Patients Organization (CCF)

Vibeke Binder and Povl Riis Foundation

Scientific Council at Herlev Hospital

Sigrid Rigmor Moran Foundation

Aage and Johanne Louis-Hansens Foundation

Munkholm Foundation

C.C. Klestrup and Henriette Klestrup Foundation

Knud and Dagny Gad Andresens Foundation

Else and Mogens Wedell-Wedellsborgs Foundation

Direktor Jacob Madsen and Olga Madsens Foundation

ScanVet

Torben og Alice Frimodt Foundation

Laegernes forsikringsforening af 1891

Bengt Ihre's foundation, Nanna Svartz' foundation

Örebro University Hospital Research Foundation

Örebro County Research Foundation

Swedish Foundation for Gastrointestinal research

Swedish Research Council

Swedish Society of Medicine

Research Council of South-East Sweden

County Council of Östergötland

Swedish Organization for the study of inflammatory bowel disease

Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital

European Crohn's and Colitis Organization

Available from: 2014-09-19 Created: 2014-09-19 Last updated: 2017-10-18Bibliographically approved

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Zhulina, YaroslavaHalfvarson, Jonas

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Örebro University HospitalSchool of Health and Medical Sciences, Örebro University, Sweden
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