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Electroporation therapy of skin cancer in the head and neck area.
Department of Otolaryngology, Örebro University Hospital, Örebro, Sweden.
Department of Otolaryngology, Örebro University Hospital, Örebro, Sweden.
Örebro University, School of Medicine, Örebro University, Sweden. Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden.
Department of Oncology, Örebro University Hospital, Örebro, Sweden.
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2010 (English)In: Dermatologic Surgery, ISSN 1076-0512, E-ISSN 1524-4725, Vol. 36, no 8, 1245-50 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Electroporation therapy is a new cancer treatment modality in which a locally applied electrical field enhances cell membrane permeability, allowing greater intracellular accumulation of a chemotherapeutic agent.

OBJECTIVE: To evaluate the efficacy of electroporation therapy in treating basal cell and squamous cell carcinomas of the skin.

MATERIALS AND METHODS: Six patients with skin cancer of the head and neck were treated using electroporation therapy with intratumorally injected bleomycin. Orbital growth, facial nerve proximity, or proximity to cartilage of the external meatus complicated four of these tumors. The intention was curative. The follow-up period was 24 months and included biopsies after 8 weeks.

RESULTS: In four of the six patients, one treatment was enough to eradicate the tumor. In one patient, the tumor persisted even after a second treatment with electroporation therapy. A septal cartilage perforation was the only major complication. The cosmetic results were very satisfactory. One additional recurrence was recorded 6 months after the follow-up period

CONCLUSION: Electroporation therapy is a promising new cancer treatment that should be further evaluated as an alternative to surgery, especially in complicated skin cancer.

Place, publisher, year, edition, pages
2010. Vol. 36, no 8, 1245-50 p.
Keyword [en]
Electroporation therapy, tumor control, basal cell carcinoma, squamous cell carcinoma, BCC, SCC
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:oru:diva-37223DOI: 10.1111/j.1524-4725.2010.01617.xISI: 000280457400005PubMedID: 20666812Scopus ID: 2-s2.0-77955152383OAI: oai:DiVA.org:oru-37223DiVA: diva2:750554
Note

Funding agencies:

Orebro County Council  

Inovio Biomedical Corporation  

Genetronics, Inc. 

Genetronics, Inc. provided financial support for this study and has paid Dr. L. Lofgren an honorarium forwork at investigator meetings.

Available from: 2014-09-29 Created: 2014-09-29 Last updated: 2017-10-17Bibliographically approved
In thesis
1. Curative electrochemotherapy in the head and neck area
Open this publication in new window or tab >>Curative electrochemotherapy in the head and neck area
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university, 2015. 94 p.
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 117
National Category
Surgery
Research subject
Surgery
Identifiers
urn:nbn:se:oru:diva-42215 (URN)978-91-7529-061-4 (ISBN)
Public defence
2015-03-06, Universitetssjukhuset, Bomanssonsalen, Södra Grev Rosengatan, Örebro, 13:00 (English)
Opponent
Supervisors
Available from: 2015-01-26 Created: 2015-01-26 Last updated: 2017-10-17Bibliographically approved

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Crafoord, SvenLöfgren, Lennart A.

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