oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Experimental vitreous tamponade using polyalkylimide hydrogel
Departments of Ophthalmology, Örebro University Hospital, Örebro, Sweden.
Departments of Ophthalmology, University of Lund, Lund, Sweden.
Departments of Ophthalmology, University of Lund, Lund, Sweden.
2011 (English)In: Graefe's Archives for Clinical and Experimental Ophthalmology, ISSN 0721-832X, E-ISSN 1435-702X, Vol. 249, no 8, 1167-74 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To evaluate polyalkylimide as a possible vitreous tamponading agent.

METHODS: A 20-gauge pars plana vitrectomy and posterior vitreous detachment were performed in the right eye of six pigmented rabbits. Approximately 1 ml of viscoelastic gel, polyalkylimide (Bio-Alcamid) was thereafter injected into the vitreous space. Full-field ERG and intraocular pressure (IOP, Tonopen) was measured pre-and postoperatively at regular intervals up to 28 days. At day 6 or 28, the rabbits were sacrificed and the eyes were examined macroscopically, photographed, and prepared for histological examination with routine microscopy.

RESULTS: The viscoelastic hydrogel was successfully injected, and remained translucent with preserved gel properties throughout the postoperative period. The postoperative IOP was unchanged compared to preoperative values. Five of six eyes displayed retinal edema or pigmentary changes centrally while the periphery appeared intact. ERG recordings showed a radical decrease in rod- and cone-derived B-wave amplitudes. Histological examination confirmed varying degrees of edema combined with neuronal cell death within the retinal layers in the central part of the fundus, while the peripheral part appeared intact.

CONCLUSION: Polyalkylimide displays favourable physical properties when used as a vitreous tamponade. However, the hydrogel causes functional and morphological retinal damage when in direct contact with the inner retina. Possible pathological mechanisms include osmotic imbalance and direct toxic effects, and modification of biochemical properties is warranted before clinical use will be possible.

Place, publisher, year, edition, pages
2011. Vol. 249, no 8, 1167-74 p.
Keyword [en]
Vitreous. Vitrectomy, Photoreceptor death
National Category
Ophthalmology Surgery
Research subject
Surgery
Identifiers
URN: urn:nbn:se:oru:diva-37220DOI: 10.1007/s00417-011-1652-6ISI: 000293642300008PubMedID: 21452039Scopus ID: 2-s2.0-80052713545OAI: oai:DiVA.org:oru-37220DiVA: diva2:750559
Note

Funding agencies:

- Faculty of Medicine, University of Lund  - Swedish Research Council  - Torsten and Ragnar Soderberg Foundation  - Departments of Ophthalmology Orebro University Hospital 

Available from: 2014-09-29 Created: 2014-09-29 Last updated: 2017-10-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Crafoord, Sven
In the same journal
Graefe's Archives for Clinical and Experimental Ophthalmology
OphthalmologySurgery

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 258 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf