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Transmission of hepatitis C virus by transfusion in Orebro County, Sweden, 1990-1992
Departments of Transfusion Medicine and Immunohemotherapy, Örebro Medical Center Hospital, Örebro, Sweden.
Departments of Infectious Diseases, Örebro Medical Center Hospital, Örebro, Sweden.ORCID iD: 0000-0001-7248-0910
Departments of Clinical Microbiology and Immunology, Örebro Medical Center Hospital, Örebro, Sweden.
Departments of Division of Clinical Virology, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden.
1995 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, E-ISSN 1651-1980, Vol. 27, no 5, 449-452 p.Article in journal (Refereed) Published
Abstract [en]

A retrospective study of hepatitis C virus (HCV) transmission by transfusion was conducted in Orebro county. Out of the 7,900 active, registered blood donors, 21 repeatedly anti-HCV reactive (RIVA 2 positive or indeterminate) donors were diagnosed. Their 84 recipients from January 1990 through June 1992 were identified and 41 (49%) were alive in December 1992. A total of 13 anti-HCV reactive (RIBA 2 positive or indeterminate) were diagnosed in 39 investigated recipients. Of these 11 were previously undiagnosed, and seven were HCV RNA-positive. In the donor population 1.03% were anti-HCV-positive by ELISA, but only 0.09% were RIBA and HCV RNA-positive. In 1990, 0.06% of the blood components came from the HCV RNA-positive donors, and none during the first 6 months of 1992. In order to identify transfusion-transmitted HCV infections that took place before the introduction of tests for anti-HCV antibodies, patients with a history of transfusion and symptoms and signs of liver dysfunction or damage should be thoroughly tested.

Place, publisher, year, edition, pages
1995. Vol. 27, no 5, 449-452 p.
Keyword [en]
Adult; Aged; Blood Donors; Blood Transfusion; Female; Hepacivirus; Hepatitis C; Hepatitis C Antibodies; Human; Male; Middle Age; Retrospective Studies; RNA, Viral; Support, Non-U.S. Gov't; Sweden
National Category
Infectious Medicine
Research subject
Infectious Diseases
Identifiers
URN: urn:nbn:se:oru:diva-37613DOI: 10.3109/00365549509047044ISI: A1995TE67600005PubMedID: 8588133Scopus ID: 2-s2.0-0028840712OAI: oai:DiVA.org:oru-37613DiVA: diva2:753492
Available from: 2014-10-08 Created: 2014-10-08 Last updated: 2016-12-01Bibliographically approved

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