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Risk of pancreatic cancer among individuals with hepatitis C or hepatitis B virus infection: a nationwide study in Sweden
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden .
Department of Analysis and Prevention, Swedish Institute for Communicable Disease Control, Solna, Sweden .
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden .
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden .
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2013 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 109, no 11, 2917-2923 p.Article in journal (Refereed) Published
Abstract [en]

Background: A few studies indicated that hepatitis C and hepatitis B virus (HCV/HBV) might be associated with pancreatic cancer risk. The aim of this nationwide cohort study was to examine this possible association.

Methods: Hepatitis C virus- and hepatitis B virus-infected individuals were identified from the national surveillance database from 1990 to 2006, and followed to the end of 2008. The pancreatic cancer risk in the study population was compared with the general population by calculation of Standardized Incidence Ratios (SIRs), and with a matched reference population using a Cox proportional hazards regression model to calculate hazard ratios (HRs).

Results: In total 340 819 person-years in the HCV cohort and 102 295 in the HBV cohort were accumulated, with 34 and 5 pancreatic cancers identified, respectively. The SIRHCV was 2.1 (95% confidence interval, CI: 1.4, 2.9) and the SIRHBV was 1.4 (0.5, 3.3). In the Cox model analysis, the HR for HCV infection was 1.9 (95% CI: 1.3, 2.7), diminishing to 1.6 (1.04, 2.4) after adjustment for potential confounders.

Conclusion: Our results indicated that HCV infection might be associated with an increased risk of pancreatic cancer but further studies are needed to verify such association. The results in the HBV cohort indicated an excess risk, however, without statistical significance due to lack of power.

Place, publisher, year, edition, pages
London, United Kingdom: Nature Publishing Group, 2013. Vol. 109, no 11, 2917-2923 p.
Keyword [en]
Adolescent, Adult, Aged. Aged, 80 and over, Child, Cohort Studies, Female, Hepatitis B, Hepatitis C, Humans, Male, Middle Aged, Pancreatic Neoplasms, Risk Factors, Sweden, Young Adult
National Category
Cancer and Oncology Infectious Medicine
Research subject
Oncology; Infectious Diseases
Identifiers
URN: urn:nbn:se:oru:diva-37652DOI: 10.1038/bjc.2013.689ISI: 000327762700022PubMedID: 24178755Scopus ID: 2-s2.0-84888878716OAI: oai:DiVA.org:oru-37652DiVA: diva2:753823
Available from: 2014-10-09 Created: 2014-10-09 Last updated: 2017-09-27Bibliographically approved

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