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CRIM1 is expressed at higher levels in drug-resistant than in drug-sensitive myeloid leukemia HL60 cells
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Clinical Research Center, Örebro University Hospital, Örebro.
Department of Medicine, Örebro University Hospital, Örebro.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Medicine, Örebro University Hospital, Örebro.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
2010 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 30, no 10, 4157-61 p.Article in journal (Refereed) Published
Abstract [en]

Aim: The aim of this study was to explore possible differences in the mRNA expression levels of CRIM1, SMAD5, BMP4 and BMP7 in sensitive (S) and multidrug-resistant (R0.5) myeloid leukemia HL60 cells.

Materials and Methods: HL60S and HL60R0.5 cells were exposed to daunorubicin (DNR) or cytarabine (Ara-C).

Results: Baseline levels of CRIM1 were found to be 15-fold higher in HL60R0.5 than in HL60S. Sixteen hours of exposure to DNR resulted in a 5.6-fold increase in CRIM1 levels in HL60S. Exposure to either DNR or Ara-C resulted in modest increases in CRIM1 levels in HL60R0.5. Similarly, baseline levels of SMAD5 and BMP4 were higher in HL60R0.5 than in HL60S cells. Analysis of the drug SMAD5-resistance marker permeability-glycoprotein (Pgp) revealed that CRIM1 and Pgp exhibit a covariance pattern of expression.

Conclusion: This study demonstrated that CRIM1 is expressed at high levels in resistant leukemia cells, indicating that CRIM1 may play a role in drug-resistance.

Place, publisher, year, edition, pages
Athens, Greece: International Institute of Anticancer Research, 2010. Vol. 30, no 10, 4157-61 p.
National Category
Medical and Health Sciences Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-37784ISI: 000283914400040PubMedID: 21036735Scopus ID: 2-s2.0-78650228378OAI: oai:DiVA.org:oru-37784DiVA: diva2:756389
Available from: 2014-10-17 Created: 2014-10-15 Last updated: 2017-10-17Bibliographically approved

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