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Folic acid supplementation and methylenetetrahydrofolate reductase (MTHFR) gene variations in relation to IVF pregnancy outcome
Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden.
Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden.
Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden.
Department of Paediatrics, School of Medicine, University of Granada, Granada, Spain; Competence Centre on Reproductive Medicine and Biology.
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2014 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 94, no 1, 65-71 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To study folic acid intake, folate status and pregnancy outcome after infertility treatment in women with different infertility diagnoses in relation to methylenetetrahydrofolate reductase (MTHFR) 677C>T, 1298A>C and 1793G>A polymorphisms. Also the use of folic acid supplements, folate status and the frequency of different gene variations were studied in women undergoing infertility treatment and fertile women.

DESIGN: Observational study.

SETTING: University hospital.

POPULATION: Women undergoing infertility treatment and healthy, fertile, non-pregnant women.

METHODS: A questionnaire was used to assess general background data and use of dietary supplements. Blood samples were taken to determine plasma folate and homocysteine levels, and for genomic DNA extraction. A comparison of four studies was performed to assess pregnancy outcome in relation to MTHFR 677 TT vs. CC, and 1298 CC vs. AA polymorphisms.

MAIN OUTCOME MEASURES: Folic acid supplement intake, and plasma folate, homocysteine and genomic assays.

RESULTS: Women in the infertility group used significantly more folic acid supplements and had better folate status than fertile women, but pregnancy outcome after fertility treatment was not dependent on folic acid intake, folate status or MTHFR gene variations.

CONCLUSION: High folic acid intakes and MTHFR gene variations seem not associated with helping women to achieve pregnancy during or after fertility treatment.

Place, publisher, year, edition, pages
2014. Vol. 94, no 1, 65-71 p.
Keyword [en]
Folate, folic acid, homocysteine, infertility, methylenetetrahydrofolate reductase, pregnancy outcome
National Category
Nutrition and Dietetics
Research subject
Nutrition
Identifiers
URN: urn:nbn:se:oru:diva-38300DOI: 10.1111/aogs.12522ISI: 000346704100012PubMedID: 25283235Scopus ID: 2-s2.0-84919360179OAI: oai:DiVA.org:oru-38300DiVA: diva2:759905
Note

Funding Agencies:

Family Planning Foundation and Fodelsefonden, Uppsala, Sweden

Regional Research Foundation, Örebro, Sweden

Pampers Scholarship, Sweden

R&D grants from Praktikertjanst AB, Stockholm, Sweden

Available from: 2014-10-31 Created: 2014-10-31 Last updated: 2017-10-17Bibliographically approved

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