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The Metabolically Healthy But Obese Phenotype Is Associated With Lower Plasma Levels of Persistent Organic Pollutants as Compared to the Metabolically Abnormal Obese Phenotype
Institut de Recherches Cliniques de Montréal, Montréal, QC, H2W 1R7, Canada; Montreal Diabetes Research Centre, Centre de Recherche du Centre Hospitalier de L'Université de Montréal (CRCHUM), Montréal, QC, H1W 4A4, Canada.
Institut de Recherches Cliniques de Montréal, Montréal, QC, H2W 1R7, Canada; Montreal Diabetes Research Centre, Centre de Recherche du Centre Hospitalier de L'Université de Montréal (CRCHUM), Montréal, QC, H1W 4A4, Canada; Nutrition Department, Université de Montréal, Canada; Endocrinology Division, Montreal University Hospital, Montréal, QC, H2W 1T8, Canada; School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Institut de Recherche de L'Hôpital Montfort, Ottawa, ON, K1K 0T2, Canada .
Department of Kinanthropology, Université du Québec À Montréal, Montréal, QC, H3C 3P8, Canada .
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2014 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 99, no 6, E1061-E1066 p.Article in journal (Refereed) Published
Abstract [en]

Context: Although obesity is strongly linked to insulin resistance and type 2 diabetes, a subset of obese individuals termed metabolically healthy but obese(MHO) appears relatively protected from the development of cardiometabolic complications. The origins of this metabolically healthy phenotype remain unclear. Recently, persistent organic pollutants (POPs) have emerged as potential endocrine disruptors.

Objective: The aim of this study was to test the hypothesis that the MHO phenotype presents lower circulating levels of POPs as compared to the metabolically abnormal obese (MAO) phenotype.

Design, Setting, and Patients: We conducted a cross-sectional study of 76 nondiabetic obese (body mass index >= 30 kg/m(2)) postmenopausal women.

Main Outcome Measures: Plasma concentrations of 21 POPs as well as cardiometabolic risk factors were analyzed.

Results: For similar age, body mass index, and fat mass index, MHO women (n = 40) showed higher insulin sensitivity levels and a more favorable cardiometabolic profile than MAO women (n = 36), as evidenced by a 2-fold increase in glucose disposal rates measured by the hyperinsulinemic-euglycemic clamp (P = .001). Among 18 detectable pollutants measured, MAO women had higher plasma concentrations of 12 POPs (fold increase, 1.4-2.9; P < .001-.036). Logistic regression analyses showed that the prevalence of the MAO phenotype was significantly associated with higher levels of total dioxin and non-dioxin-like polychlorinated biphenyls (odds ratio, 4.7; 95% confidence interval, 1.8-12.5; P = .002), as well as trans-nonachlor (odds ratio, 6.1; 95% CI, 2.2-16.4; P < .001).

Conclusion: Our study demonstrates that the metabolically healthy and abnormal phenotypes have distinct plasma POP profiles.

Place, publisher, year, edition, pages
2014. Vol. 99, no 6, E1061-E1066 p.
National Category
Chemical Sciences
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-38248DOI: 10.1210/jc.2013-3935ISI: 000342340500018PubMedID: 24606089Scopus ID: 2-s2.0-84899864055OAI: oai:DiVA.org:oru-38248DiVA: diva2:760049
Note

Funding Agencies:

Genome Quebec (CAO project)

J-A DeSeve Chair for Clinical Research

Canadian Institutes of Health Research New Emerging Team in Obesity (University of Montreal and University of Ottawa, MONET project) T 0602145.02

Norwegian Diabetes Association

Grieg Foundation

China Scholarship Council 201206400003

Research Council of Norway 228135

Available from: 2014-11-03 Created: 2014-10-30 Last updated: 2017-10-17Bibliographically approved

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