oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Mixtures of chemical pollutants at European legislation safety concentrations: how safe are they?
European Commission-DG Joint Research Centre, Institute for Environment and Sustainability, Italy.
Norwegian University of Science & Technology, Trondheim, Norway.
National Institute for Industrial Environment and Risks, Verneuil en Halatte, France.
National Institute for Industrial Environment and Risks, Verneuil en Halatte, France Reims University, France.
Show others and affiliations
2014 (English)In: Toxicological Sciences, ISSN 1096-6080, E-ISSN 1096-0929, Vol. 141, no 1, 218-233 p.Article in journal (Refereed) Published
Abstract [en]

The risk posed by complex chemical mixtures in the environment to wildlife and humans is increasingly debated, but has been rarely tested under environmentally relevant scenarios. To address this issue, two mixtures of 14 or 19 substances of concern (pesticides, pharmaceuticals, heavy metals, polyaromatic hydrocarbons, a surfactant, and a plasticizer), each present at its safety limit concentration imposed by the European legislation, were prepared and tested for their toxic effects. The effects of the mixtures were assessed in 35 bioassays, based on 11 organisms representing different trophic levels. A consortium of 16 laboratories was involved in performing the bioassays. The mixtures elicited quantifiable toxic effects on some of the test systems employed, including i) changes in marine microbial composition, ii) microalgae toxicity, iii) immobilization in the crustacean Daphnia magna, iv) fish embryo toxicity, v) impaired frog embryo development, and vi) increased expression on oxidative stress-linked reporter genes. Estrogenic activity close to regulatory safety limit concentrations was uncovered by receptor-binding assays. The results highlight the need of precautionary actions on the assessment of chemical mixtures even in cases where individual toxicants are present at seemingly harmless concentrations.

Place, publisher, year, edition, pages
2014. Vol. 141, no 1, 218-233 p.
Keyword [en]
bioassays, effects, mixtures, ecotoxicology, biomarkers
National Category
Environmental Sciences
Research subject
Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-38654DOI: 10.1093/toxsci/kfu118ISI: 000342990200026PubMedID: 24958932OAI: oai:DiVA.org:oru-38654DiVA: diva2:763759
Note

Funding Agencies:

RADAR 265721

French Office Water and Aquatic Environment

French Ministry for Ecology and Sustainable Development P181 DRC50

Available from: 2014-11-17 Created: 2014-11-17 Last updated: 2017-10-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Kharlyngdoh, Joubert B.Modig, CarinaOlsson, Per-Erik

Search in DiVA

By author/editor
Kharlyngdoh, Joubert B.Modig, CarinaOlsson, Per-Erik
By organisation
School of Science and Technology
In the same journal
Toxicological Sciences
Environmental Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 276 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf