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High-Dose Supplements of Vitamins C and E, Low-Dose Multivitamins, and the Risk of Age-related Cataract: A Population-based Prospective Cohort Study of Men
Division of Nut ritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Division of Nut ritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Division of Preventive Medicine, Brigham and Women ’ s Hospital and Harvard Medical School, Boston, Massachusetts.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden.
Division of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Swede.
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2013 (English)In: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 177, no 6, 548-555 p.Article in journal (Refereed) Published
Abstract [en]

We examined the associations of high-dose supplements of vitamins C and E and low-dose multivitamins with the risk of age-related cataract among 31,120 Swedish men, aged 45-79 years, in a population-based prospective cohort. Dietary supplement use was assessed from a questionnaire at baseline in 1998. During follow-up (January 1998 December 2006), 2,963 incident age-related cataract cases were identified. The multivariable-adjusted hazard ratio for men using vitamin C supplements only was 1.21(95% confidence interval (Cl): 1.04, 1.41) in a comparison with that of non supplement users. The hazard ratio for long-term vitamin C users (>= 10 years before baseline) was 1.36 (95% Cl: 1.02, 1.81). The risk of cataract with vitamin C use was stronger among older men (>65 years) (hazard ratio = 1.92, 95% Cl: 1.41, 2.60) and corticosteroid users (hazard ratio = 2.11, 95% Cl: 1.48, 3.02). The hazard ratio for vitamin E use only was 1.59 (95% Cl: 1.12, 2.26). Use of multivitamins only or multiple supplements in addition to vitamin C or E was not associated with cataract risk. These results suggest that the use of high-dose (but not low-dose) single vitamin C or E supplements may increase the risk of age-related cataract. The risk may be even higher among older men, corticosteroid users, and long-term users.

Place, publisher, year, edition, pages
2013. Vol. 177, no 6, 548-555 p.
Keyword [en]
ascorbic acid, cataract, dietary supplements, oxidative stress, vitamin E
National Category
Public Health, Global Health, Social Medicine and Epidemiology Environmental Health and Occupational Health
Research subject
Public health
Identifiers
URN: urn:nbn:se:oru:diva-38741DOI: 10.1093/aje/kws279ISI: 000316374500008PubMedID: 23420353Scopus ID: 2-s2.0-84874886631OAI: oai:DiVA.org:oru-38741DiVA: diva2:764259
Note

Funding agencies are:

theSwedish Council for Working Life and Social Research (Dnr.2010-1064)

the Swedish Research Council/Committee for Infrastructure (Dnr. 2008-5947), Stockholm, Sweden.

Available from: 2014-11-18 Created: 2014-11-18 Last updated: 2017-10-18Bibliographically approved

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Ejdervik, Birgitta Lindblad
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CiteExportLink to record
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