High-Dose Supplements of Vitamins C and E, Low-Dose Multivitamins, and the Risk of Age-related Cataract: A Population-based Prospective Cohort Study of MenShow others and affiliations
2013 (English)In: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 177, no 6, p. 548-555Article in journal (Refereed) Published
Abstract [en]
We examined the associations of high-dose supplements of vitamins C and E and low-dose multivitamins with the risk of age-related cataract among 31,120 Swedish men, aged 45-79 years, in a population-based prospective cohort. Dietary supplement use was assessed from a questionnaire at baseline in 1998. During follow-up (January 1998 December 2006), 2,963 incident age-related cataract cases were identified. The multivariable-adjusted hazard ratio for men using vitamin C supplements only was 1.21(95% confidence interval (Cl): 1.04, 1.41) in a comparison with that of non supplement users. The hazard ratio for long-term vitamin C users (>= 10 years before baseline) was 1.36 (95% Cl: 1.02, 1.81). The risk of cataract with vitamin C use was stronger among older men (>65 years) (hazard ratio = 1.92, 95% Cl: 1.41, 2.60) and corticosteroid users (hazard ratio = 2.11, 95% Cl: 1.48, 3.02). The hazard ratio for vitamin E use only was 1.59 (95% Cl: 1.12, 2.26). Use of multivitamins only or multiple supplements in addition to vitamin C or E was not associated with cataract risk. These results suggest that the use of high-dose (but not low-dose) single vitamin C or E supplements may increase the risk of age-related cataract. The risk may be even higher among older men, corticosteroid users, and long-term users.
Place, publisher, year, edition, pages
2013. Vol. 177, no 6, p. 548-555
Keywords [en]
ascorbic acid, cataract, dietary supplements, oxidative stress, vitamin E
National Category
Public Health, Global Health, Social Medicine and Epidemiology Occupational Health and Environmental Health
Research subject
Public health
Identifiers
URN: urn:nbn:se:oru:diva-38741DOI: 10.1093/aje/kws279ISI: 000316374500008PubMedID: 23420353Scopus ID: 2-s2.0-84874886631OAI: oai:DiVA.org:oru-38741DiVA, id: diva2:764259
Note
Funding agencies are:
theSwedish Council for Working Life and Social Research (Dnr.2010-1064)
the Swedish Research Council/Committee for Infrastructure (Dnr. 2008-5947), Stockholm, Sweden.
2014-11-182014-11-182018-09-06Bibliographically approved