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Diastolic function improves after resolution of takotsubo cardiomyopathy
State University of New York, Downstate Medical Center, Brooklyn, NY, USA; Marshfield clinic-weston center, Weston, WI, USA.
Orebro University Hospital.ORCID iD: 0000-0002-4262-6373
New York Methodist Hospital, Brooklyn, NY, USA.
State University of New York, Downstate Medical Center, Brooklyn, NY, USA.
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2016 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 6, no 1, 17-24 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Takotsubo cardiomyopathy (TTC) is a condition of reversible left ventricular (LV) systolic dysfunction. However, the diastolic function (DF) manifestations of TTC have not been widely investigated. We performed a bicentric study with retrospective analysis of DF in patients with TTC, during onset and at follow-up.

METHODS: Twenty-eight patients with TTC (64 ± 10 years, F 24) were included. All underwent echocardiograms acutely and at the recovery phase (average three months later). Diastolic and systolic function parameters were recorded, including E-wave velocity (E), A-wave velocity, E/A ratio, relaxation (e') and contractility (S') based on tissue Doppler velocities of the mitral annuli, ejection fraction (EF), left atrial (LA) size and DF stages.

RESULTS: Recovery, including the mean difference with 95% confidence interval, was associated with tending improvement (i.e. uncorrected significance) in E [13 cm s(-1) (-24, -2·3), P = 0·02] and in E/A ratio [0·2 (-0·41, -0·02), P = 0·04], as well as significant improvement (after multiple comparison correction) in mean e' [2·0 cm s(-1) (-3·3, -1·2), P<0·001] and in A-wave duration [29 ms (-46·7, -12·7), P = 0·002]. LA area tended to decrease during recovery [-2 cm² (0·33, 2·4), P = 0·01]. Improvement in DF stages was significant between the phases (21% versus 58% defined as normal DF, P = 0·016). Improvement in LVEF correlated with improvement in mean e' (r = 0·52, P = 0·02).

CONCLUSIONS: TTC is associated with an acute impairment of conventional DF variables, which improves during recovery. DF recovery seems to occur in parallel with systolic recovery in patients with TTC.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2016. Vol. 6, no 1, 17-24 p.
Keyword [en]
broken heart syndrome, doppler, echocardiography, relaxation, stress-induced cardiomyopathy
National Category
Cardiac and Cardiovascular Systems Physiology
Research subject
Cardiology
Identifiers
URN: urn:nbn:se:oru:diva-38859DOI: 10.1111/cpf.12188ISI: 000368343700003PubMedID: 25208087Scopus ID: 2-s2.0-84910667384OAI: oai:DiVA.org:oru-38859DiVA: diva2:764915
Available from: 2014-11-20 Created: 2014-11-20 Last updated: 2017-03-17Bibliographically approved

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Waldenborg, MicaelLoiske, KarinEmilsson, Kent
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